Evidence map›Paper›PMID 40995691›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Time-Dependent Therapeutic Effect of S-Ketamine on PTSD Mediated by VTA-OFC Dopaminergic Neurocircuit.

Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Investigational drugs in PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ye WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Lei LiuDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Jinghao WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Jiannan LiDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Huiming LiDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Rui WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Hui WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Min WangDepartment of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Quanying LiuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Zhongmin FanDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Yunyun ZhangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Xinxin ZhangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Dan WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Sa WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Rou XueDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Jindong MaoDepartment of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Min CaiDepartment of Psychiatry, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Pengfei WeiSchool of Biological Science and Medical Engineering, State Key Laboratory of Digital Medicine, Southeast University, Nanjing, 211189, China.
Hailong DongDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Yumei WuDepartment of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Guangchao ZhaoDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.ORCID https://orcid.org/0000-0001-7842-3773

Funding

Joint Founding Project of Innovation Research Institute, Xijing Hospital LHJJ24JH02National Natural Science Foundation of China 82030038National Natural Science Foundation of China 82071515National Natural Science Foundation of China 82221001National Natural Science Foundation of China 82271211National Natural Science Foundation of China 82293643National Natural Science Foundation of China 82430040National Natural Science Foundation of China 82501821National Science and Technology Major Project 2025ZD0218300Young Elite Scientist Sponsorship Program by CAST YESS20220212
6 · The paper itself

Abstract

Current pharmacotherapies for post-traumatic stress disorder (PTSD) are limited by delayed onset and side effects. Despite ketamine exhibiting rapid relief of the core symptoms of PTSD, its clinical efficacy varies considerably depending on the timing of drug delivery. However, the underlying mechanism remains unclear. In this study, the therapeutic effects of early (day 1) and late (day 7) administration of S-Ketamine on behavioral phenotypes in rodent's models of PTSD are compared. It is observed that early rather than late administration of S-Ketamine significantly ameliorates PTSD symptoms, especially impaired fear extinction. The firing and burst rates of VTA

Indexed as

Dopaminergic NeuronsKetaminePrefrontal CortexStress Disorders, Post-TraumaticVentral Tegmental AreaAnimalsDisease Models, AnimalExtinction, PsychologicalFearMaleRatsRats, Sprague-DawleyTime FactorsKetaminePTSDS‐ketamineTI‐NIBSVTA dopamine

Identifiers

PMID40995691
PMCPMC12697765

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.