ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- qEEG and Functional Connectivity as a Translational Bridge Between Humans and Dogs in Epilepsy and Associated Disorders: From Spontaneous Model to Automatic Classification-An Integrative Review.Veterinary sciences · 2026Review
- A canine brain bank for comparative neuroscience and brain aging research.bioRxiv : the preprint server for biology · 2026Article
- Alzheimer's Disease Neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function.Research square · 2026Article
- Increased neurotoxic gliosis and blood-brain barrier dysregulation in canine cognitive dysfunction syndrome (CCD).Frontiers in aging · 2026Article
- Untargeted plasma metabolomics in canine cognitive dysfunction: the naturally occurring Alzheimer's disease analog in dogs.Frontiers in neuroscience · 2026Article
- The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
introductionCanine cognitive dysfunction is a valuable model for Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) due to condensed lifespan, naturally occurring clinical signs, genetic diversity, shared environment with humans, and similar molecular and neuropathological hallmarks.
methodsThe objective of the Brain Health Study was to build infrastructure to support a diverse national cohort of companion dogs for in-depth, longitudinal analysis of brain and cognitive health over their lifespan. A complex and well-maintained research platform was critical to facilitate enrollment, retention, and biobanking of biofluids and postmortem tissue.
resultsThe research infrastructure is in place for longitudinal data collection, annual biospecimen collection and postmortem sample collection. The team has conducted 21 postmortem exams. DISCUSSION: Although most of the 500 enrolled subjects remain alive, biomarker identification, neuropathology, and proteomics analysis is underway. Future outcomes will benefit the worldwide research community through an Open Data sharing platform. HIGHLIGHTS: The dog serves as a novel translational large animal model for Alzheimer's disease (AD) and ad and related dementias. A large research platform supports collection of biofluids and post mortem tissue. The companion dog has key molecular and neuropathological hallmarks of AD. The Brain Health Study research platform has successfully enrolled 500 dogs across the United States. Post mortem biofluid and tissue has been donated from 21 enrolled dogs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.