Evidence map›Paper›PMID 40995968›Full record

ArticlePediatric pulmonology2025

Caffeine for Persistent Intermittent Hypoxia in Newborns With and Without Chronic Lung Disease.

Aurore Côté, Phoukim Savanh, Wissam Shalish, Victoria Bizgu, Anne-Marie Canakis

Abstract read
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In one paragraph

Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aurore CôtéRespiratory Medicine Division, Room B-RC-5155, The Montreal Children's Hospital, Montreal, Québec, Canada.ORCID 0009-0009-3824-3781
Phoukim SavanhNeonatology Division, The Jewish General Hospital, Montréal, Québec, Canada.
Wissam ShalishNeonatology Division, The Montreal Children's hospital, Montreal, Québec, Canada.ORCID 0000-0002-7435-1466
Victoria BizguNeonatology Division, The Jewish General Hospital, Montréal, Québec, Canada.
Anne-Marie CanakisRespiratory Medicine Division, The Montreal Children's Hospital, Montreal, Québec, Canada.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

objectivesTo assess the caffeine response in preterm and term newborns with persistent intermittent hypoxia (IH) as they approach discharge, with particular focus on newborns with chronic lung disease of prematurity (CLD). To identify factors associated with a lack of response to caffeine. DESIGN/SETTINGS: Retrospective cohort study across two neonatal intensive care units between 2015 and 2022. MAIN OUTCOMES FOLLOWING CAFFEINE ADMINISTRATION: Normal oximetry; no need for respiratory support; resolution of hypercapnia.

resultsA total of 132 infants received caffeine for persistent IH. Normal oximetry was achieved post-caffeine in 81% (46/57) of newborns with CLD, in 96% (46/48) of preterm with no CLD, in 96% (26/27) of term newborns. Caffeine reduced the % time with SpO

conclusionCaffeine improved respiratory outcomes in the majority of preterm and term born infants with persistent IH, including those with CLD.

Indexed as

CaffeineHypoxiaLung DiseasesChronic DiseaseFemaleHumansHypercapniaInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleOximetryRetrospective StudiesCaffeinehypercapniaoximetryventilator support

Identifiers

PMID40995968
PMCPMC12462228

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.