Evidence map›Paper›PMID 40996290›Full record

ArticleMicrobiology spectrum2025

Advancing antifungal therapy: exploring targeted CFW-PEc-enhanced ethosomal formulations of amphotericin B against cryptococcal pneumonia.

Guoting Shi, Mengshun Li, Lili Chu, Baocheng Tian, Mengxin Li, Haiyan Wang, Huihui Zhou, Yanchun Han, Chunxiao Meng, Chen Ding and 1 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guoting Shi *School of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Mengshun Li *School of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Lili ChuSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Baocheng TianSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Mengxin LiSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Haiyan WangSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Huihui ZhouDepartment of pathology, Affiliated Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.
Yanchun HanSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Chunxiao MengSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.ORCID 0000-0002-8347-7917
Chen DingCollege of Life and Health Science, Northeastern University, Shenyang, China.ORCID 0000-0002-9195-2255
Sixiang SaiSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.ORCID 0000-0002-7665-0128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IMPORTANCE: Cryptococcal pneumonia presents a significant global health burden with limited therapeutic options due to inherent toxicity and suboptimal bioavailability of conventional antifungal agents. This investigation demonstrates the innovative application of calcofluor white-phosphatidylethanolamine conjugate (CFW-PEc) to enhance amphotericin B (AmB) delivery via ethosomes for cryptococcal infection treatment. Our findings elucidate that CFW-PEc significantly potentiates the antifungal efficacy of AmB-loaded ethosomes against

Indexed as

Amphotericin BAntifungal AgentsCryptococcosisCryptococcus neoformansPhosphatidylethanolaminesPneumoniaAnimalsDisease Models, AnimalDrug Delivery SystemsFemaleHumansMiceMice, Inbred BALB CMicrobial Sensitivity TestsParticle SizeAmphotericin BAntifungal AgentsphosphatidylethanolaminePhosphatidylethanolaminesantifungal activityCFW-PEc-AmB-ethosomesCryptococcus neoformansdrug delivery systems

Identifiers

PMID40996290
PMCPMC12584715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.