Evidence map›Paper›PMID 40996549›Full record

ReviewLasers in medical science2025

Photobiomodulation by infrared radiation on hallmarks of cancer.

Ana Caroline da Silva Ferreira, Thayssa Gomes Farias, Ana Julia Cardoso Borges, Marcelle Abreu da Silva, Bruno Ricardo Barreto Pires, Andre Luiz Mencalha, Adenilson de Souza da Fonseca

Abstract readReview
PubMed Publisher
In one paragraph

Review in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Caroline da Silva FerreiraDepartamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Boulevard Vinte e Oito de Setembro, 87, Rio de Janeiro, 20551030, Rio de Janeiro, Brazil. ferreira.sanacaroline@gmail.com.
Thayssa Gomes FariasDepartamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Boulevard Vinte e Oito de Setembro, 87, Rio de Janeiro, 20551030, Rio de Janeiro, Brazil.
Ana Julia Cardoso BorgesDepartamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Boulevard Vinte e Oito de Setembro, 87, Rio de Janeiro, 20551030, Rio de Janeiro, Brazil.
Marcelle Abreu da SilvaDepartamento de Ciências Fisiológicas, Universidade Federal do Estado do Rio de Janeiro, Rua Frei Caneca, 94, Rio de Janeiro, 25964004, Rio de Janeiro, Brazil.
Bruno Ricardo Barreto PiresDepartamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Boulevard Vinte e Oito de Setembro, 87, Rio de Janeiro, 20551030, Rio de Janeiro, Brazil.
Andre Luiz MencalhaDepartamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Boulevard Vinte e Oito de Setembro, 87, Rio de Janeiro, 20551030, Rio de Janeiro, Brazil.
Adenilson de Souza da FonsecaDepartamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Boulevard Vinte e Oito de Setembro, 87, Rio de Janeiro, 20551030, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photobiomodulation (PBM) is a therapeutic technique that utilizes non-ionizing radiation, such as infrared radiation, which is capable of stimulating or inhibiting biological processes. Cancer is characterized by uncontrolled cell growth and proliferation in any body structure, allowing it to invade other tissues. Cancer exhibits distinct biological characteristics, the so-called hallmarks of cancer. Despite the therapeutic benefits of PBM, and cancers affect millions of people worldwide, the mechanisms involved in PBM, as those induced by infrared A radiation, on cancer are not yet fully elucidated. Thus, we aimed to review the effects of PBM induced by infrared radiation on the hallmarks of cancer. For this, studies on the effects of PBM induced by infrared A radiation on in vitro and in vivo experimental models of cancer were accessed via MEDLINE/PubMed. The data accessed showed that effects of PBM induced by infrared A radiation were evaluated on four hallmarks of cancer (sustaining proliferative signaling, evading growth suppressors, genomic instability and mutation, and resisting cell death) but not on the other ten ones (enabling replicative immortality, non-mutational epigenetic reprogramming, avoiding immune destruction, tumor-promoting inflammation, polymorphic microbiomes, activating invasion and metastasis, inducing or accessing vasculature, senescent cells, deregulation cellular energetics, unlocking phenotypic plasticity). Thus, considering the therapeutic benefits of PBM, evaluation of the effects of PBM on the hallmarks of cancer can also bring such benefits to oncologic patients.

Indexed as

Infrared RaysLow-Level Light TherapyNeoplasmsAnimalsCell ProliferationGenomic InstabilityHumansCancerInfrared radiationPhotobiomodulation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.