Evidence map›Paper›PMID 40996575›Full record

ArticleVeterinary research communications2025

Response of broiler chickens to dietary different yeast cell wall components challenged with Salmonella typhimurium.

Pinar Sacakli, Elsayed Mickdam, Alev Gurol Bayraktaroglu, Burcu Ekim, Ozge Sizmaz

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Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pinar SacakliDepartment of Animal Nutrition & Nutritional Diseases, Faculty of Veterinary Medicine, Ankara University, Ankara, 06110, Turkey.
Elsayed MickdamNutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.
Alev Gurol BayraktarogluDepartment of Histology Embryology, Faculty of Veterinary Medicine, Ankara University, Ankara, 06110, Turkey.
Burcu EkimLife Sciences Research and Application Centre, Gazi University, Ankara, 06830, Turkey.
Ozge SizmazDepartment of Animal Nutrition & Nutritional Diseases, Faculty of Veterinary Medicine, Ankara University, Ankara, 06110, Turkey. osizmaz@ankara.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the impact of dietary prebiotic supplementation on broiler chickens challenged with Salmonella Typhimurium. In experiment I, the treatments consisted of control (K) [without supplementation]; supplemented with 0.565% autolyzed whole yeast cell (W); supplemented with 0.125% autolyzed whole yeast cell (WP); supplemented with 0.565% enzymatically removed yeast cell wall (CELL) and supplemented with 0.2% pure Mannan-oligosaccharides (MOS) + β-glucan (MB). The second experiment, the Salmonella Typhimurium challenge was performed on day 7 post-hatch. Birds in the CELL group in Experiment I exhibited higher final body weight and weight gain (P = 0.001). On day 21, jejunum villus height (VH) was lower in the MB group, while jejunum crypt depth (CD) was lower in the WP and K groups (P < 0.05). The W group had the lowest VH and CD in the ileum (P < 0.05). At day 35, jejunal villus health was unaffected by prebiotic supplementation, but the CELL group showed the highest VH and CD in the ileum (P < 0.05). Gene expression analysis revealed significant differences in claudin, IL-1β, and IL-10 expressions. In experiment II, the CELL group exhibits the highest final live body weight and weight gain (P < 0.05). Intestinal histology varied among groups and time points. Gene expression analysis indicated upregulation of claudin and occludin in certain groups, while IL-1β was upregulated in all groups and IL-10 showed varied expressions. In conclusion, prebiotic supplementation, particularly yeast cell wall, positively influenced broiler performance, intestinal histology, and gene expression related to the intestinal barrier.

Indexed as

Cell WallChickensPoultry DiseasesPrebioticsSalmonella Infections, AnimalSalmonella typhimuriumYeastsAnimal FeedAnimalsDietDietary SupplementsJejunumMalePrebioticsBroilerPrebioticShort chain fatty acidsΒ-glucan

Identifiers

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.