Evidence map›Paper›PMID 40996650›Full record

ArticleBulletin of experimental biology and medicine2025

"Homeostatic" Cytokines Enhance the Expression of PD-1, Tim-3, and Their Ligands on Myeloid Cells.

O Yu Leplina, M A Tikhonova, E V Batorov, T V Tyrinova, E R Chernykh

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

O Yu LeplinaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia. oleplina@mail.ru.
M A TikhonovaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E V BatorovResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
T V TyrinovaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E R ChernykhResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the expression of checkpoint molecules in monocyte subsets and monocytic myeloid-derived suppressor cells (M-MS) and the effect of homeostatic cytokines (IL-2, IL-7, IL-15) on the expression of PD-1/PD-L1 and Tim-3/Galectin-9 by myeloid cells. Monocytes and M-MS were shown to express PD-1 and Tim-3, and the proportions of PD-1

Indexed as

B7-H1 AntigenCytokinesHepatitis A Virus Cellular Receptor 2Multiple MyelomaMyeloid-Derived Suppressor CellsProgrammed Cell Death 1 ReceptorAgedFemaleGalectinsHumansInterleukin-15Interleukin-2Interleukin-7MaleMiddle AgedMonocytesB7-H1 AntigenCD274 protein, humanCytokinesGalectinsHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2IL15 protein, humanIL2 protein, humanIL7 protein, humanInterleukin-15Interleukin-2Interleukin-7LGALS9 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 Receptorcheckpoint moleculeshomeostatic cytokinesmonocytesmyeloid-derived suppressor cells

Identifiers

PMID40996650

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.