Evidence map›Paper›PMID 40996935›Full record

ArticleDevelopmental neuroscience2025

Association between Cold-Inducible RNA-Binding Motif 3 and Hypothermia Effect in Murine Hypoxia-Ischemia Model Measured by Hyperpolarized

Xiaodan Liu, Xiangning Jiang, Alkisti Mikrogeorgiou Capper, Nicholas Stewart, Will Byrne, Xiao Ji, Jacob Ellison, Duan Xu, Donna M Ferriero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaodan LiuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Xiangning JiangDepartment of Neurology and Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Alkisti Mikrogeorgiou CapperColorado State University, Fort Collins, Colorado, USA.
Nicholas StewartDepartment of Neurology and Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Will ByrneDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Xiao JiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Jacob EllisonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Duan XuDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Donna M FerrieroDepartment of Neurology and Pediatrics, University of California, San Francisco, San Francisco, California, USA.

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Precision Therapy for Neonatal Brain InjuryR35NS097299 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 2017 to 2024
$6.3M
A critical role for microglial cholesterol 25-hydroxylase in regulating neuroinflammation following neonatal brain hypoxia-ischemiaR21NS133533 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JIANG, XIANGNING · 2024 to 2025
$450k
NIBIB NIH HHS P41 EB013598NINDS NIH HHS R21 NS133533NINDS NIH HHS R35 NS097299
6 · The paper itself

Abstract

introductionThe efficacy of therapeutic hypothermia (TH) for neonatal hypoxic-ischemic encephalopathy (HIE) is inconsistent, and the cause remains unclear. This study aimed to explore the role of cold stress protein in the TH-induced neuroprotection following hypoxia-ischemia (HI) using hyperpolarized carbon-13 MRI (HP-13C MRI).

methodsPostnatal day 10 (P10) mice underwent unilateral HI followed by treatments with TH or normothermia (NT). HI and sham mice were scanned at 4 h and 22 h following TH after injection of hyperpolarized 13C-1 labeled pyruvate. The dynamic HP [1-13C] MR spectroscopic images (MRSI) were acquired to examine the cerebral metabolic profile, i.e., the conversion rate from pyruvate to lactate (k

resultsWe observed the upregulation of RBM3 during TH at 4 h and 22 h after TH. The spectrin 145/150 and spectrin 120 were unchanged over time in HI+TH group, whereas they significantly increased at 18 h and 22 h in HI+NT group. Additionally, the injury size was noticeably larger at 22 h in HI+NT group. Lower k

conclusionThis study demonstrates that RBM3 may be one of the key factors associated with TH-induced neuroprotection by reducing the anaerobic glycolysis process in HI mice, suggesting RBM3 upregulation may enhance the efficacy of TH for neonatal HIE.

Indexed as

Cerebral metabolismCold stress proteinHyperpolarized 13C MR spectroscopic imagingHypoxia-ischemia

Identifiers

PMID40996935
PMCPMC12659713

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.