ArticlePloS one2025
Role of weight-adjusted waist circumference index and non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio in prediabetes risk: A mediation analysis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to investigate the prevalence of prediabetes among U.S. adults using NHANES 2017-2023 data, explore the relationship between the weight-adjusted waist circumference index (WWI) and the non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (NHHR) and the risk of prediabetes, and provide a theoretical foundation for the early identification and intervention of prediabetes.
methodsLogistic regression, linear regression model, subgroup analysis, restricted cubic spline (RCS) analysis, and mediation analysis were employed to examine the effect of WWI on prediabetes and the mediating role of NHHR.
resultsA total of 9,713 adults were included in the analysis, with an age range of 20-80 and a mean age of 51.26 ± 17.25. Of these, 3,208 cases (33.03%) were prediabetic. The adjusted model showed that WWI (OR = 1.55, 95% CI: 1.46, 1.64) may increase the probability of prediabetes. The results of subgroup analysis, stratified by factors such as gender and age, largely supported these findings. The adjusted model also indicated that NHHR (OR = 1.20, 95% CI: 1.16, 1.25) may increase the probability of prediabetes. The RCS analysis revealed a nonlinear relationship between both WWI and NHHR with the risk of prediabetes. Further mediation analysis indicated that NHHR mediated 10% of the effect of WWI on prediabetes.
conclusionWWI and NHHR were significantly associated with the risk of prediabetes, and NHHR partially mediated the effect of WWI on prediabetes. This study provides a new theoretical basis for early prediabetes screening, prevention, and control. In the future, interventions targeting WWI and NHHR through lifestyle changes may be effective in preventing prediabetes.
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