Evidence mapPaperPMID 40997178Full record

ReviewScience (New York, N.Y.)2025

From reactive to proactive: Continuous protein monitoring for preventive health care.

Jane M Donnelly, Ryan A Neff, Andrew J H Sedlack, Vuslat B Juska, Luis Fernando Ayala-Cardona, Joseph Bass, Elizabeth M McNally, Sanjiv J Shah, Nabil Alshurafa, Eyal Y Kimchi and 2 more

Abstract readReview
In one paragraph

Review in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jane M Donnelly *Department of Chemistry, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-6160-0179
Ryan A Neff *Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-7876-0112
Andrew J H Sedlack *Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0003-0139-952X
Vuslat B JuskaDepartment of Chemistry, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-7727-6249
Luis Fernando Ayala-CardonaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-7971-561X
Joseph BassDivision of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-1602-8601
Elizabeth M McNallyCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-1221-719X
Sanjiv J ShahDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-5655-8201
Nabil AlshurafaDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-6681-7564
Eyal Y KimchiDepartment of Neurology, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-4327-1102
G R Scott BudingerDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-3114-5208
Shana O KelleyDepartment of Chemistry, Northwestern University, Evanston, IL, USA.ORCID 0000-0003-3360-5359

Funding

Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY · 2022 to 2025
$20.7M
HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targetsU54HL160273 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$3.3M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$2.9M
The Cell Phenotyping and Mouse CoreP01HL154998 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$2.2M
Delirium Dynamics: Understanding Causes and EffectsR01AG078261 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$782k
Role of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgeryR01HL147575 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$773k
Reagentless Sensor Technologies For Continuous Monitoring of Heart Failure BiomarkersR01HL165002 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$751k
Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19R01HL158139 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$723k
Pathogenesis of lung injury mediated by lung-restricted antibodiesR01HL147290 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$679k
Integration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$486k
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity PathophysiologyR01DK127800 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$434k
Continuous monitoring of epidermal inflammatory response to mechanical strainF31AR086577 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$50k
CSRD VA I01 CX001777NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL128076NHLBI NIH HHS R01 HL147290NHLBI NIH HHS R01 HL147575NHLBI NIH HHS R01 HL158139NHLBI NIH HHS R01 HL165002NHLBI NIH HHS U54 HL160273NIAID NIH HHS U19 AI135964NIAMS NIH HHS F31 AR086577NIA NIH HHS P01 AG049665NIA NIH HHS R01 AG078261NIA NIH HHS R21 AG075423NIA NIH HHS U54 AG079754NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK127800
6 · The paper itself

Abstract

Continuous biomarker monitoring is revolutionizing chronic disease management, with glucose monitoring for diabetes as the primary example. Given the success of this approach, a transition to continuous protein monitoring (CPM, a real-time, implantable or wearable technology) could similarly advance precision medicine. In this work, we review state-of-the-art CPM platforms and their prospective clinical impact across both chronic disorders-metabolic, cardiovascular, autoimmune, and neurodegenerative-and acute crises, such as sepsis and transplant dysfunction. We also highlight remaining barriers to widespread adoption, including sensor stability, robust machine learning models for live interpretation, and responsible data handling for patient privacy. With continued engineering and clinical validation, emerging biosensor technologies could transform disease management, facilitating earlier interventions and individualizing treatment strategies, ultimately improving patient outcomes.

Indexed as

Biosensing TechniquesPreventive Health ServicesProteinsBiomarkersChronic DiseaseHumansMachine LearningMonitoring, PhysiologicPrecision MedicineWearable Electronic DevicesBiomarkersProteins

Identifiers

PMID40997178
PMCPMC12687573

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.