ArticleCell reports. Medicine2025
The multiomics blueprint of the individual with the most extreme lifespan.
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Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
13 citing papers in PubMed.
- Article
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- The gut microbiome and ageing trajectories: mechanisms and clinical implications.Nature reviews. Endocrinology · 2026Review
- Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians.Cell reports. Medicine · 2026Article
- Ultra-Processed Foods and Chronic Kidney Disease: Is Inflammaging the Missing Link?Biomolecules · 2026Review
- The long-lived immune system of centenarians.Nature reviews. Immunology · 2026Review
- Age-related transcriptional drift and physiological adaptation in long-living Ames dwarf skeletal muscle.NAR molecular medicine · 2026Article
- Fanconi anaemia as a human model of accelerated epigenetic and immune ageing.Ageing research reviews · 2026Review
- Epigenetic Clocks, Resilience, and Multi-Omics Ageing: A Review and the EpiAge-R Conceptual Framework.International journal of molecular sciences · 2026Review
- Biological age and immunosenescence in Colombian centenarians.npj aging · 2026Article
- The pursuit of understanding human longevity.npj aging · 2026Article
- Marmoset (Callithrix jacchus) Swallowing Physiology: Novel Dysphagia Model Across Lifespan.Integrative and comparative biology · 2026Article
- Healthy diet and slower biological aging as protective factors against microvascular complications in type 2 diabetes.GeroScience · 2025Article
Corrections and comments
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Authors and funding
58 authors.
Eloy Santos-PujolCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Aleix Noguera-CastellsCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Department of Biosciences, Faculty of Science, Technology and Engineering, University of Vic - Central University of Catalonia (UVic-UCC), Vic, Barcelona, Catalonia, Spain; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
Marta Casado-PelaezCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Carlos A García-PrietoCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Catalonia, Spain.
Claudia VasalloBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain; Institute of Evolutionary Biology (IBE, UPF-CSIC), Department of Medicine and Life, Barcelona, Catalonia, Spain.
Ignacio Campillo-MarcosCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
Carlos Quero-DotorCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
Eva Crespo-GarcíaCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Alberto Bueno-CostaCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Fernando SetiénCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Gerardo FerrerCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
Veronica DavalosCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
Elisabetta MereuCellular Systems Genomics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Raquel PluvinetGenomics Unit, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; High Content Genomics and Bioinformatics (HCGB)-Germans Trias I Pujol Research Institute (IGTP), Badalona, Barcelona, Catalonia, Spain.
Carles ArribasGenomics Unit, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Carolina de la TorreProteomics Unit, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Francisco VillavicencioDepartment of Economic, Financial and Actuarial Mathematics, University of Barcelona, Barcelona, Catalonia, Spain.
Lauro SumoyHigh Content Genomics and Bioinformatics (HCGB)-Germans Trias I Pujol Research Institute (IGTP), Badalona, Barcelona, Catalonia, Spain.
Isabel GranadaHematology Department, Hospital Germans Trias i Pujol, Institut Català d'Oncologia, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
Natalie S ColesLos Angeles Gerontology Research Group, Los Angeles, CA, USA.
Pamela AchaMyelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Francesc SoléMyelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Mar MalloMyelodysplastic Syndromes Research Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Microarrays Unit, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Caterina MataSingle Cell Unit, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
Sara PeregrinaLife Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Catalonia, Spain; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.
Toni GabaldónLife Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Catalonia, Spain; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, Barcelona, Catalonia, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
Marc LlirósBioinformatics and Bioimaging (BI-SQUARED) Research Group, Biosciences Department, Faculty of Science, Technology and Engineering, Universitat de Vic - Universitat Central de Catalunya, Vic, Catalunya, Spain.
Meritxell PujolassosBioinformatics and Bioimaging (BI-SQUARED) Research Group, Biosciences Department, Faculty of Science, Technology and Engineering, Universitat de Vic - Universitat Central de Catalunya, Vic, Catalunya, Spain.
Robert Carreras-TorresDigestive Diseases and Microbiota Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), Girona, Catalonia, Spain.
Aleix LluansíDigestive Diseases and Microbiota Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), Girona, Catalonia, Spain; Infectious diseases and Microbiome Unit, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Catalunya, Spain.
Librado Jesús García-GilDigestive Diseases and Microbiota Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), Girona, Catalonia, Spain; Biology Department, Universitat de Girona, Girona, Catalunya, Spain.
Xavier AldeguerDigestive Diseases and Microbiota Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), Girona, Catalonia, Spain; Digestive Service, Hospital Universitari de Girona Dr Josep Trueta, Girona, Catalunya, Spain.
Sara SaminoBiosfer Teslab, 43201 Reus, Tarragona, Spain.
Pol TornéBiosfer Teslab, 43201 Reus, Tarragona, Spain.
Josep RibaltaUniversitat Rovira i Virgili, Department of Basic Medical Sciences, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili, Reus, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Montse GuardiolaUniversitat Rovira i Virgili, Department of Basic Medical Sciences, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili, Reus, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Núria AmigóBiosfer Teslab, 43201 Reus, Tarragona, Spain; Universitat Rovira i Virgili, Department of Basic Medical Sciences, Reus, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Oscar YanesInstitut d'Investigació Sanitària Pere Virgili, Reus, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Universitat Rovira i Virgili, Department of Electronic Engineering, Tarragona, Spain.
Paula MartínezTelomeres and Telomerase Group - Fundación Humanismo y Ciencia, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Raúl Sánchez-VázquezTelomeres and Telomerase Group - Fundación Humanismo y Ciencia, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Maria A BlascoTelomeres and Telomerase Group - Fundación Humanismo y Ciencia, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
Jose OviedoDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA.
Bernardo LemosDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA; Coit Center for Longevity and Neurotherapeutics, The University of Arizona, Tucson, AZ, USA.
Julia Rius-BonetBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain; epi4health, Faculty of Health Sciences, Universitat Oberta de Catalunya, 08018 Barcelona, Catalonia, Spain.
Marta Torrubianoepi4health, Faculty of Health Sciences, Universitat Oberta de Catalunya, 08018 Barcelona, Catalonia, Spain.
Marta Massip-SalcedoBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain; epi4health, Faculty of Health Sciences, Universitat Oberta de Catalunya, 08018 Barcelona, Catalonia, Spain.
Kamal A KhidirMechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK; University of Raparin, Kurdistan Region, Iraq.
Thong Huy CaoDepartment of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester LE1 7RH, UK; National Institute for Health and Care Research Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester LE3 9QP, UK; Leicester van Geest MultiOMICS Facility, University of Leicester, Leicester LE1 7RH, UK.
Paulene A QuinnDepartment of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester LE1 7RH, UK; Leicester van Geest MultiOMICS Facility, University of Leicester, Leicester LE1 7RH, UK.
Donald J L JonesLeicester van Geest MultiOMICS Facility, University of Leicester, Leicester LE1 7RH, UK; Leicester Cancer Research Centre, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, University of Leicester, Leicester LE1 5WW, UK.
Salvador MacipBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain; epi4health, Faculty of Health Sciences, Universitat Oberta de Catalunya, 08018 Barcelona, Catalonia, Spain; Mechanisms of Cancer and Aging Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK.
Eva Brigos-BarrilInstitute of Evolutionary Biology (IBE, UPF-CSIC), Department of Medicine and Life, Barcelona, Catalonia, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, PRBB, Barcelona, Spain.
Mauricio MoldesCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.
Fabio BarteriBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain.
Gerard MuntanéDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, PRBB, Barcelona, Spain; Hospital Universitari Institut Pere Mata (HUIPM), Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), Catalonia, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Hafid LaayouniBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, PRBB, Barcelona, Spain.
Arcadi NavarroBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain; Institute of Evolutionary Biology (IBE, UPF-CSIC), Department of Medicine and Life, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, Barcelona, Catalonia, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, PRBB, Barcelona, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.
Manel EstellerCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, Barcelona, Catalonia, Spain; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain. Electronic address: mesteller@carrerasresearch.org.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.
Indexed as
AgingLongevityAged, 80 and overEpigenomeFemaleHumansMaleMetabolomeMicrobiotaMultiomicsProteomeTranscriptomeProteomeagingepigeneticsgeneticsmicrobiomesupercentenarian
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