ArticleGut2026
Hereditary diffuse gastric cancer spectrum associated with germline
Abstract read
In one paragraph
Article in Gut, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Hereditary diffuse gastric cancer in progress: Comparative lessons from Lynch syndrome.European journal of human genetics : EJHG · 2026Review
- Germline whole-exome sequencing identifies CTNND1 as a candidate gene for hereditary gastric cancer in a large Brazilian cohort.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Cuproplasia-associated LOXL2 cooperates withJournal of gastrointestinal oncology · 2026Article
- Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges.International journal of cancer · 2026Review
- Artificial intelligence-driven personalized dietary recommendations for gastric cancer high-risk populations: a narrative review.Frontiers in nutrition · 2026Review
- Hereditary diffuse gastric cancer: between underdiagnosis and overtreatment: a case series.Frontiers in surgery · 2026Article
- The Changing Landscape of Hereditary Diffuse Gastric Cancer.Journal of gastric cancer · 2026Review
- The interplay of the microbiome, host genetics, and epigenetic modifications in gastric cancer.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
56 authors.
Silvana Loboi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.ORCID 0000-0002-5705-2958
Alexandre Diasi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.
Ana Maria Pedroi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.
Marta Ferreirai3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.
André Pinto-Oliveirai3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.
Celina São Joséi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.ORCID 0000-0003-4292-3957
Jennifer Herrera-MullarAmbry Genetics Corporation, Aliso Viejo, California, USA.
Nádia Pintoi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.
Chrystelle ColasDepartment of Genetics, Institut Curie, Paris, France.ORCID 0000-0001-9146-9346
Robert HüneburgDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-9957-8299
Jacob NattermannDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-5972-0780
Lise BoussemartImmunology and New Concepts in ImmunoTherapy, Nantes Université, Nantes, France.
Liselotte P van HestDepartment of Human Genetics, Section Clinical Genetics, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
Leticia MoreiraDepartment of Gastroenterology; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clinic de Barcelona, Barcelona, Spain.ORCID 0000-0002-4518-8591
Carolyn HortonAmbry Genetics Corporation, Aliso Viejo, California, USA.
Dana Farengo ClarkDivision of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Sigrid TinschertDivision of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Lisa GolmardDepartment of Genetics, Institut Curie, Paris, France.
Isabel SpierNational Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.
Adriá López-FernándezHereditary Cancer Genetics Group, Medical Oncology Department, Vall d'Hebron Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain.
Daniela OliveiraMedical Genetics Unit, Paediatric Hospital, Coimbra Hospital and University Centre, Coimbra, Portugal.
Magali SvrcekEquipe Instabilité Des Microsatellites Et Cancer, Centre de Recherche Saint Antoine, Sorbonne Université, Paris, France.
Pierre BourgoinSorbonne Université, Laboratoire D'anatomie Et Cytologie Pathologiques, Hôpital Saint-Antoine, Paris, France.
Florence CouletDépartement de Génétique médicale, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France.
Hélène DelhomelleDepartment of Genetics, Institut Curie, Paris, France.
Jeremy DavisCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-6334-6936
Birthe ZänckerInstitut für Klinische Genetik, Universitätsklinikum CarlGustav Carus, Dresden, Germany.
Conxi LazaroHereditary Cancer Program, Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell) Program; Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
Joana GuerraCancer Genetics Group and Department of Laboratory Genetics, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network), Portuguese Oncology Institute of Porto (IPO-Porto)/Porto Comprehensive Cancer Center (Porto.CCC), Francisco Gentil Portuguese Institute for Oncology of Porto, Porto, Portugal.
Maria L AlmeidaULSBraga - Unidade Local de Saúde de Braga, Braga, Portugal.
Sergio CarreraGenetic Counseling Unit-Medical Oncology Department, Cruces University Hospital, Barakaldo, Spain.
Ana PatiñoMedical Genomics Unit, Cancer Center; Laboratory of Advanced Therapies for Pediatric Solid Tumors, Cancer Division, University Clinic of Navarra, Pamplona, Spain.
Paul GundlachDepartment of Clinical Genetics, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Monika LaszkowskaGastroenterology, Hepatology, and Nutrition Service, Department of Subspecialty Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Vivian E StrongMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Manuel R TeixeiraICBAS -School of Medicine and Biomedical Sciences of the University of Porto, Portugal, Porto, Portugal.
Intan SchraderHereditary Cancer Program, BC Cancer Agency, Vancouver, British Columbia, Canada.ORCID 0000-0002-7413-4314
Verena Steinke-LangeMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
Irene Gulloi3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.
Sérgio SousaMedical Genetics Unit, Paediatric Hospital, Coimbra Hospital and University Centre, Coimbra, Portugal.
Manuela BatistaServiço de Cirurgia Geral, Unidade Local de Saúde São João, Porto, Portugal.
Stefan AretzNational Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.
Judith BalmañaHereditary Cancer Genetics Group, Medical Oncology Department, Vall d'Hebron Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain.
Melyssa AronsonZane Cohen Centre, Sinai Health System, Toronto, Ontario, Canada.
Augusto Perazzolo AntoniazziCancer Genetics Departament, Barretos Cancer Hospital, Barretos, Brazil.
Edenir I PalmeroMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
Paul MansfieldThe University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Lizet E van der KolkDepartment of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Annemieke CatsDepartment of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jolanda M van DierenDepartment of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Sergi Castellví-BelDepartment of Gastroenterology; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clinic de Barcelona, Barcelona, Spain.
Bryson KatonaDivision of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Rachid KaramAmbry Genetics Corporation, Aliso Viejo, California, USA.
Paulo S Pereirai3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal.
Patrick R BenusiglioDépartement de Génétique médicale, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France.
Carla Oliveirai3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal, Porto, Portugal carlaol@i3s.up.pt.ORCID 0000-0001-8340-2264
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MNCI NIH HHS P30 CA008748
Abstract
backgroundDiffuse gastric cancer (DGC) is the most common manifestation in germline
objectiveExplore
designUsing molecular, clinical and population data from 1308 individuals from 351
results
conclusionWe provide compelling evidence supporting that
Indexed as
alpha CateninStomach NeoplasmsAdultAgedAnimalsCadherinsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansLoss of Function MutationMaleMiddle Agedalpha CateninCadherinsCTNNA1 protein, humanADHESION MOLECULESCANCER GENETICSGASTRIC CANCERHEREDITARY CANCER SYNDROMESMODELS, ANIMALS
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.