Evidence map›Paper›PMID 40998969›Full record

ArticleScientific reports2025

Effects of anserine on oxidative stress and on cell barrier integrity in methylmalonic aciduria.

Felix Köpfer, Maria Bartosova Medvid, Thomas Fleming, Tilman Pfeffer, Jürgen Günther Okun, Stefan Kölker, Georg Friedrich Hoffmann, Claus Peter Schmitt, Marina Morath, Verena Peters

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Felix KöpferDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.
Maria Bartosova MedvidDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.
Thomas FlemingMedical Faculty Heidelberg, Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg University, 69120, Heidelberg, Germany.
Tilman PfefferDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.
Jürgen Günther OkunDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.
Stefan KölkerDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.
Georg Friedrich HoffmannDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.
Claus Peter SchmittDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.
Marina MorathDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany. marina.morath@med.uni-heidelberg.de.
Verena PetersDivision of Pediatric Neurology and Metabolic Medicine, Department of Pediatrics I, Medical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, 69120, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney damage in individuals with methylmalonyl-CoA mutase deficiency (mut

Indexed as

Amino Acid Metabolism, Inborn ErrorsOxidative StressAdenosine TriphosphateAntioxidantsCell LineCell SurvivalEpithelial CellsHumansMitochondriaOxygen ConsumptionZonula Occludens-1 ProteinAdenosine TriphosphateAntioxidantsZonula Occludens-1 ProteinAnserineHuman immortalized kidney tubule cellMetabolic cell stressMethylmalonic aciduriaOxidative stress

Identifiers

PMID40998969
PMCPMC12464228

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.