Evidence map›Paper›PMID 40998976›Full record

ArticleScientific reports2025

Effects of oral glucose tolerance test on microvascular and autonomic nervous system regulation in young healthy individuals.

Lana Kralj, Tadej Battelino, Helena Lenasi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lana KraljInstitute of Physiology, Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia.
Tadej BattelinoDepartment of Pediatric Endocrinology, Diabetes and Metabolism, University Children's Hospital, University Medical Centre Ljubljana, and Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia.
Helena LenasiInstitute of Physiology, Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia. helena.lenasi.ml@mf.uni-lj.si.

Funding

The Slovenian Research and Innovation Agency P3-0019The Slovenian Research and Innovation Agency P3-0343
6 · The paper itself

Abstract

Acute elevations in blood glucose can influence microvascular function and autonomic nervous system (ANS) reactivity, both implicated in cardiometabolic risk. We assessed the effects of oral glucose tolerance test (OGTT) on microvascular and ANS physiological responses in healthy young individuals. Using laser Doppler flowmetry (LDF), we measured basal skin microcirculatory blood flow and responses to post-occlusive reactive hyperemia, iontophoresis of acetylcholine (ACh), and sodium nitroprusside (SNP) in 28 participants before and 45 and 120 min after OGTT or water loading. LDF spectral components were analyzed using wavelet analysis (WA). ANS reactivity was evaluated from electrocardiogram recordings by analyzing heart rate variability (HRV). OGTT caused time-dependent changes in microvascular and HRV parameters. Endothelial nitric oxide-independent vasodilation transiently decreased during SNP response (p = 0.014), while myogenic component transiently increased (p = 0.029; two-way repeated measures ANOVA), with no significant change in the endothelial nitric oxide-dependent component. HRV measures RMSSD (p = 0.009) and SDNN (p = 0.008) decreased. Oral glucose loading affects microcirculation in healthy individuals, likely through modulation of endothelial nitric oxide-independent signaling, vascular smooth muscle responsiveness, and ANS reactivity. WA may offer a sensitive method for detecting microvascular dysfunction associated with physiological changes following oral glucose loading.

Indexed as

Autonomic Nervous SystemGlucose Tolerance TestMicrovesselsAcetylcholineAdultBlood GlucoseFemaleHumansLaser-Doppler FlowmetryMaleMicrocirculationNitroprussideSkinVasodilationAcetylcholineBlood GlucoseNitroprussideAcute hyperglycemiaEndothelial functionHeart rate variabilityMicrocirculationNitric oxideOral glucose loadingOral glucose tolerance testWavelet analysis

Identifiers

PMID40998976
PMCPMC12464305

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.