Evidence map›Paper›PMID 40999355›Full record

ArticleBMC genomics2025

Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits.

Jinpeng Wang, Yaran Zhang, Chunhong Yang, Zhihua Ju, Yao Xiao, Qiang Jiang, Wenhao Liu, Xiuge Wang, Xiaochao Wei, Yaping Gao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jinpeng WangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Yaran ZhangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Chunhong YangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Zhihua JuKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Yao XiaoKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Qiang JiangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Wenhao LiuKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Xiuge WangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Xiaochao WeiKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Yaping GaoKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Xiuxin ZhaoShandong Technology Innovation Center of Dairy Cattle Breeding Industry, Ji'nan, 250100, China.
Lingling WangShandong Technology Innovation Center of Dairy Cattle Breeding Industry, Ji'nan, 250100, China.
Yundong GaoKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Jianbin LiKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China.
Jinming HuangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Gongye North Road 23788, Ji'nan, Shandong Province, 250100, China. huangjinm@sina.com.

Funding

Earmarked Fund for Modern Agro-industry Technology Research System CARS-36National Key Research and Development Program of China 2021YFF1000703Natural Science Foundation of Shandong Province ZR2024MC139
6 · The paper itself

Abstract

backgroundThe genomic diversity of Chinese Holstein cattle remains insufficiently characterized, and the identification of genes associated with body conformation traits is still limited. In this study, we aimed to explore the genome-wide diversity and population structure, and to identify candidate genes associated with 20 body conformation traits in Chinese Holstein cattle from six farms using the GGP Bovine 50 K single nucleotide polymorphism (SNP) chip.

resultsWe analyzed runs of homozygosity and population admixture across farms and observed genetic diversity differences among herds. A genome-wide association study identified 21 significant SNPs linked to five body conformation traits. Notably, a missense mutation in TJP1 (BovineHD2100008355) was associated with foot heel depth. Ten SNPs within intronic regions of genes such as GABRG3, NEGR1, and CDH2 were associated with various udder and leg traits. The remaining ten SNPs were located in intergenic regions and influenced transcription factor binding sites. Among them, BovineHD2100013266, BovineHD0500004109, and BTB-00042676 were shown to regulate transcriptional activity through dual-luciferase reporter assays.

conclusionsOur findings offer valuable insights for managing genetic inbreeding in cattle farms, enhancing the understanding of the genetic architecture underlying body conformation traits in Holstein cattle, and accelerating the genomic selection process in Chinese Holsteins.

Indexed as

Genetic VariationGenome-Wide Association StudyGenomicsAnimalsCattleChinaPhenotypePolymorphism, Single NucleotideQuantitative Trait LociBody conformation traitsFunction validationGenome-wide association analysisGenomic diversityRuns of homozygosity

Identifiers

PMID40999355
PMCPMC12465292

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.