Evidence map›Paper›PMID 40999526›Full record

SynthesisStem cell research & therapy2025

Clinical efficacy and safety of somatic cell therapy for chronic low back pain: evidence from the pooled randomized controlled trials.

Zihao Li, Yuming Sun, Shaorong Lei, Yikun Zhang, Hang Lin, Yuanheng Yang, Wuyuan Tan

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zihao LiDepartment of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China.
Yuming SunDepartment of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China.
Shaorong LeiDepartment of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China.
Yikun ZhangDepartment of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China.
Hang LinCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, USA.
Yuanheng YangDepartment of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China. yuanhengyang@csu.edu.cn.
Wuyuan TanDepartment of Plastic and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha, China. darma_tan@aliyun.com.ORCID http://orcid.org/0000-0001-8062-403X

Funding

Natural Science Foundation of Hunan Province 2020JJ4907
6 · The paper itself

Abstract

backgroundChronic low back pain (CLBP) is a highly prevalent and burdensome musculoskeletal disorder globally, significantly impacting individuals' health and quality of life. This study aimed to evaluate the efficacy and safety of the somatic cell therapies in treating CLBP.

methodsAll relevant randomized controlled trials (RCTs) in the Cochrane, Embase, PubMed, and Web of Science databases were systematically searched for the meta-analysis. The outcomes consisted of Visual Analogue Scale (VAS) scores, Oswestry Disability Index (ODI) scores, and the incidence of serious adverse events (SAE). Dichotomous outcomes were described as odds ratios (OR) with 95% confidence intervals (CIs), while continuous data were presented as mean difference (MD) with 95% CIs. Statistical analysis was performed with RevMan 5.4 and stata 17 software.

resultsA total of seven RCTs involving 518 patients were included in the meta-analysis. The results showed that somatic cell therapies were effective in terms of VAS scores [MD = -12.04 (-17.35,-6.72)] and ODI scores [MD = -8.03 (-12.84,-3.22)], while not increasing risk of SAE [OR = 0.70 (0.19, 2.64)].

conclusionsOur findings suggested that somatic cell therapy demonstrated significant therapeutic efficacy in the management of CLBP. Future large-scale, multicenter RCTs with extended follow-up durations are warranted to confirm the optimal somatic cell type and dosage regimen for maximal therapeutic benefit.

Indexed as

Cell- and Tissue-Based TherapyChronic PainLow Back PainHumansQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeChronic low back painMeta-analysisSomatic cell

Identifiers

PMID40999526
PMCPMC12465977

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.