Evidence map›Paper›PMID 40999952›Full record

ArticleMolecular medicine reports2025

HSPD1 regulates angiotensin II‑induced atrial fibrillation via the PPAR signaling pathway.

Yimeng Zhou, Lianzhi Zhang, Shunping Zhou, Wenjia Zhang, Qunlin Gong, Nan Xu, Jiahong Wang, Zhong Zhang, Nannan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yimeng Zhou *Department of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Lianzhi Zhang *Department of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Shunping Zhou *Department of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Wenjia ZhangDepartment of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Qunlin GongDepartment of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Nan XuDepartment of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Jiahong WangDepartment of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Zhong ZhangDepartment of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.
Nannan ChenDepartment of Cardiology, School of Medicine, Yangpu Hospital, Tongji University, Shanghai 200090, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is a multifactorial condition, and understanding its molecular mechanisms is key for developing targeted therapies. The present study aimed to investigate the role of heat shock protein D1 (HSPD1) in the pathogenesis of AF, particularly in angiotensin II (Ang II)‑induced cardiac fibroblasts (CFs). Differentially expressed genes (DEGs) were screened from the GSE31821 dataset for enrichment analysis, protein‑protein interaction (PPI) network construction and the hub gene HSPD1 was identified.

Indexed as

Angiotensin IIAtrial FibrillationHeat-Shock ProteinsPeroxisome Proliferator-Activated ReceptorsSignal TransductionCell MovementCell SurvivalChaperonin 60CytokinesFibroblastsGene Expression RegulationHumansMitochondrial ProteinsMolecular ChaperonesProtein Interaction MapsAngiotensin IIChaperonin 60CytokinesHeat-Shock ProteinsHSPD1 protein, humanMitochondrial ProteinsMolecular ChaperonesPeroxisome Proliferator-Activated Receptorsangiotensin IIatrial fibrillationheat shock protein D1peroxisome proliferator‑activated receptor signaling pathway

Identifiers

PMID40999952
PMCPMC12511845

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.