Evidence mapPaperPMID 40999988Full record

ReviewOncology reports2025

Neuroscience in glioma biology (Review).

Chunzhi Zhang, Hanning Zhang, Jiahao Cao, Meili Liu

Abstract readReview
In one paragraph

Review in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chunzhi Zhang *Department of Radiation Oncology, Tianjin Hospital, Tianjin University, Tianjin 300211, P.R. China.
Hanning Zhang *Clinical Medical College of Tianjin Medical University, Tianjin 300270, P.R. China.
Jiahao CaoTianjin Medical University, Tianjin 300203, P.R. China.
Meili LiuDepartment of Radiology, Tianjin Huanhu Hospital, Tianjin 300222, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although our understanding of the molecular and cellular factors involved in the development and growth of glioma has increased, prognosis remains dismal in most patients. The emerging field of cancer neuroscience has revealed the intricate functional interplay between glioma and the cellular architecture of the brain, especially neural circuits. In recent years, studies have revealed that glioma cells integrate and remodel multicellular neural circuits. Neural circuits have thus emerged as critical regulators of glioma from initiation to malignant growth. In the present review, an updated framework was provided for understanding the construction of neuron‑glioma networks and the mechanisms by which neurons regulate the malignant phenotype of glioma. Readers will also obtain insights into the construction of glioma‑glioma networks formed by tumor microtubes. Furthermore, the present review reveals the complex interconnectivity among the nervous system, immune system and glioma that promotes tumor growth. Finally, some potential areas of clinical translation and new research directions were highlighted.

Indexed as

Brain NeoplasmsGliomaAnimalsBrainHumansNerve NetNeuronsNeurosciencesgliomaneural circuitsneuronneurosciencesynapse

Identifiers

PMID40999988
PMCPMC12511927

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.