ArticleFrontiers in physiology2025
The thermogenic effect of mirabegron ingestion during cool conditions.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Adipose Tissue Browning in MASLD and Its Molecular Mechanisms and Metabolic Crosstalk.Current obesity reports · 2026Review
- Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition.Frontiers in nutrition · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Brown adipose tissue (BAT) is highly thermogenic and can be stimulated by cold exposure or mirabegron, a β3-adrenergic receptor agonist. However, it is currently not known whether the thermogenic effects of mirabegron are observed during exposure to cool temperatures. We tested the hypotheses that energy expenditure and BAT activation would be greater following mirabegron ingestion versus a placebo (PLA). Methods: Eleven healthy adults (5 women) completed four, double-blind, randomized visits to the laboratory involving the acute ingestion of 100, 150, and 200 mg of mirabegron or PLA. Following ingestion, subjects rested for 6 h in a whole-body indirect room calorimeter (20 °C, 50% RH). Cumulative energy expenditure was calculated for each study visit. Using infrared thermography, supraclavicular BAT activity was assessed via the area under the curve (AUC) for supraclavicular skin temperature (Tsc) expressed relative to sternal skin temperature for each visit. Results: Cumulative energy expenditure was greater following ingestion of 100 mg (494 ± 75 kcal; Discussion: Our data indicate β3-adrenergic receptor activation of supraclavicular BAT via mirabegron ingestion enhances thermogenesis in cool environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.