Evidence mapPaperPMID 41000191Full record

ArticleBioinformatics advances2025

EMICSS: added-value annotations for EMDB entries.

Amudha Kumari Duraisamy, Neli Fonseca, Gerard J Kleywegt, Ardan Patwardhan, Kyle L Morris

Abstract read
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amudha Kumari DuraisamyElectron Microscopy Data Bank, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire CB10 1SD, United Kingdom.ORCID https://orcid.org/0000-0002-1282-6438
Neli FonsecaElectron Microscopy Data Bank, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire CB10 1SD, United Kingdom.ORCID https://orcid.org/0000-0001-6466-8083
Gerard J KleywegtElectron Microscopy Data Bank, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire CB10 1SD, United Kingdom.ORCID https://orcid.org/0000-0002-4670-0331
Ardan PatwardhanElectron Microscopy Data Bank, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire CB10 1SD, United Kingdom.ORCID https://orcid.org/0000-0001-7663-9028
Kyle L MorrisElectron Microscopy Data Bank, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire CB10 1SD, United Kingdom.ORCID https://orcid.org/0000-0002-1717-8134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: The electron microscopy data bank (EMDB) is a key repository for three-dimensional electron microscopy (3DEM) data but lacks comprehensive annotations and connections to many related biological, functional, and structural data resources. This limitation arises from the optional nature of such information to reduce depositor burden and the complexity of maintaining up-to-date external references, often requiring depositor consent. To address these challenges, we developed EMDB Integration with Complexes, Structures, and Sequences (EMICSS), an independent system that automatically updates cross-references with over 20 external resources, including UniProt, AlphaFold DB, PubMed, Complex Portal, and Gene Ontology. Results: EMICSS (https://www.ebi.ac.uk/emdb/emicss) annotations are accessible in multiple formats for every EMDB entry and its linked resources, and programmatically via the EMDB application programming interface. EMICSS plays a crucial role supporting the EMDB website, with annotations being used on entry pages, statistics, and in the search system. Availability and implementation: EMICSS is implemented in Python and it is an open-source, distributed under the Apache license version 2.0, with core code available on GitHub (https://github.com/emdb-empiar/added_annotations).

Identifiers

PMID41000191
PMCPMC12457740

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.