ArticleJournal of hepatocellular carcinoma2025
Low Indoleamine 2,3-Dioxygenase 1 Expression Enhances Dendritic Cells Response to Tumor Cells Against Hepatocellular Carcinoma.
Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To investigate the effect of IDO1 expression levels in HCC on the distribution, infiltration, and anti-tumor immune response of mature DCs. Methods: Multiplex immunohistochemical staining was applied to detect the expression level of IDO1 and the infiltration of DCs in the HCC tissue microarray, including total 96 human HCC samples and 82 samples of matched adjacent normal tissues. In vitro, CCK-8, Key Fluor 488 Click-iT Edu, wound healing, and transwell assays were performed to explore the effect of IDO1 on the viability, proliferation, migration and invasion ability of HCC cell line SK-HEP1. In vivo, a subcutaneous xenograft tumor model of nude mice was established by subcutaneously inoculating SK-HEP1 and treated with IDO1 catalytic inhibitor epacadostat (EPA) to observe the effect of IDO1 on tumor growth and immune cells infiltration. Results: Results of clinical tissue microarrays showed that compared with corresponding paracancerous tissues, the infiltration of mature DCs was significantly reduced in HCC cancer tissues with high expression of IDO1. Meanwhile, IDO1 was highly expressed in HCC cancer tissues with pathological grade I-II, high AFP levels (≥200µg/L), HBV-positivie, cirrhosis, distant metastasis and recurrence. Survival analysis showed that low IDO1 and high mature DCs cell infiltration were significantly associated with superior overall survival (OS). Correlation analysis further showed that IDO1 was negatively correlated with mature DCs. The in vitro cellular and in vivo animal experiments in this study showed that inhibition IDO1 helped to decrease the malignant biological behavior of HCC and enhance the response of immune cells to tumor cells. Conclusion: IDO1 suppresses anti-tumor immunity in HCC, at least in part, by curtailing mDC infiltration. Targeting IDO1 may represent a promising immunotherapeutic strategy. However, its immunomodulatory effects must be validated in immunocompetent or humanized animal systems before clinical translation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.