Evidence map›Paper›PMID 41000378›Full record

ArticleFrontiers in immunology2025

Peripheral blood iNKT cells display an activated profile with both increased apoptosis and dysfunction in obesity.

Chloé Wilkin, Nathalie Esser, Cédric Lassence, Marion Bruneteaux, Marjorie Fadeur, Jenny De Flines, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chloé WilkinLaboratory of Immunometabolism and Nutrition, GIGA-Immunobiology, ULiège, Liège, Belgium.
Nathalie EsserLaboratory of Immunometabolism and Nutrition, GIGA-Immunobiology, ULiège, Liège, Belgium.
Cédric LassenceLaboratory of Virology and Immunology, GIGA-Immunobiology, ULiège, Liège, Belgium.
Marion BruneteauxLaboratory of Immunometabolism and Nutrition, GIGA-Immunobiology, ULiège, Liège, Belgium.
Marjorie FadeurDivision of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, Centre Hospitalier Universitaire (CHU) of Liège, Liège, Belgium.
Jenny De FlinesDivision of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, Centre Hospitalier Universitaire (CHU) of Liège, Liège, Belgium.
Nicolas PaquotLaboratory of Immunometabolism and Nutrition, GIGA-Immunobiology, ULiège, Liège, Belgium.
Jacques PietteLaboratory of Virology and Immunology, GIGA-Immunobiology, ULiège, Liège, Belgium.
Sylvie Legrand-PoelsLaboratory of Immunometabolism and Nutrition, GIGA-Immunobiology, ULiège, Liège, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is characterized by a chronic low-grade inflammation and, paradoxically, is also associated with immune cells dysfunction. In this study, we analyzed peripheral blood Invariant Natural killer T cells (iNKT) in individuals with or without obesity. These unconventional T cells recognize lipid antigens presented by the monomorphic CD1d MHC I-like protein. We demonstrated an activation of iNKT cells in individuals with obesity associated with both increased apoptosis and dysfunction as assessed by the lack of responsiveness to PMA/Ionomycin stimulation. This disruption mainly affects the CD4

Indexed as

ApoptosisLymphocyte ActivationNatural Killer T-CellsObesityAdultAntigens, CD1dCytokinesFemaleHumansMaleMiddle AgedMonocytesAntigens, CD1dCD1D protein, humanCytokinesactivation markersCD1dcytokinesiNKTlipid antigensmonocytesobesity

Identifiers

PMID41000378
PMCPMC12457317

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.