Evidence map›Paper›PMID 41000667›Full record

ArticlebioRxiv : the preprint server for biology2025

Microglial metabolic reprogramming drives cognitive decline in heart failure with preserved ejection fraction.

Swapna Patil, Connor Lantz, Angela Marinovic, Ripon Sarkar, Bo Ryung Lee, Matthew DeBerge

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Swapna PatilDepartment of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston.
Connor LantzComprehensive Transplant Center, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago.
Angela MarinovicDepartment of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston.
Ripon SarkarDepartment of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston.
Bo Ryung LeeDepartment of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston.
Matthew DeBergeDepartment of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston.ORCID 0000-0002-9786-0327

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a rapidly growing public health concern and an emerging contributor to dementia, yet the mechanisms linking cardiometabolic dysfunction to neurodegeneration remain poorly understood. Here, we demonstrate that HFpEF drives a sustained neuroinflammatory state through microglial metabolic reprogramming. Using a clinically relevant murine model of HFpEF, we identified robust induction of HIF-1α signaling in microglia via integrated transcriptomics and metabolomics, coupled with increased glycolytic metabolism revealed by extracellular flux analysis. Conditional deletion of

Identifiers

PMID41000667
PMCPMC12458430

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.