Evidence map›Paper›PMID 41000699›Full record

ArticlebioRxiv : the preprint server for biology2025

Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset.

Ana Caroline Costa-da-Silva, Rubina Sharma, Marit H Aure, Daniel Martin, Noemi Kedei, Damilola F Killanin, Ayesha Javaid, Francis A Boksa, Drashty P Mody, Joe T Nguyen and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ana Caroline Costa-da-SilvaNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2729-5836
Rubina SharmaNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7804-0673
Marit H AureNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2080-1740
Daniel MartinNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8880-9087
Noemi KedeiCollaborative Protein Technology Resource, OSTR, Office of the Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6625-6119
Damilola F KillaninNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0000-4044-1642
Ayesha JavaidNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9346-9219
Francis A BoksaNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0002-7572-3767
Drashty P ModyNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6597-4904
Joe T NguyenNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6647-0561
Sukirth M GanesanNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6303-7287
Joshua T DodgeNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Clara H KimNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3805-0321
Marie Kao-HsiehNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3442-4453
David E KleinerLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Christopher G KanakryCenter for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7736-2056
Steven Z PavleticImmune Deficiency Cellular Therapy Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9111-9354
Jacqueline W MaysNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4472-9974

Funding

NIDCR DIR Scientific Cores (Combined Technical Research Core)ZICDE000729 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ABSHARI, MEHRNOOSH · 2009 to 2025
$31.7M
Genomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8M
Immunobiology and therapy of oral mucosal and salivary gland chronic graft-versus-host diseaseZIADE000747 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MAYS, JACQUELINE · 2016 to 2025
$14.9M
Imaging CoreZICDE000750 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DOYLE, ANDREW · 2019 to 2025
$6.9M
Intramural NIH HHS ZIA DE000747Intramural NIH HHS ZIC DC000086Intramural NIH HHS ZIC DE000729Intramural NIH HHS ZIC DE000750
6 · The paper itself

Abstract

Chronic graft-versus-host disease (cGVHD) frequently follows allogeneic hematopoietic stem cell transplantation and impacts the mucosa. This atlas study highlights the role of exhausted-like effector CD8

Identifiers

PMID41000699
PMCPMC12458946

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.