SynthesisFrontiers in nutrition2025
Impact of a high-fat, low-carbohydrate ketogenic diet on seizure frequency in children with drug-resistant epilepsy: a systematic review and Meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Ketogenic Strategies in Neonatal Hypoxic-Ischemic Encephalopathy-The Road to Opening Up: A Scoping Review.Neurology international · 2026Review
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Authors and funding
4 authors.
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Abstract
Background: Drug-resistant epilepsy in children poses significant therapeutic challenges. The ketogenic diet (KD), characterized by high-fat and low-carbohydrate content, has emerged as a potential adjunctive treatment. This meta-analysis aimed to systematically evaluate the impact of the KD on seizure frequency in pediatric patients with drug-resistant epilepsy. Methods: Following PRISMA guidelines, PubMed, Embase, Web of Science, and the Cochrane Library were searched to identify randomized and quasi-randomized trials of classical KD, modified Atkins diet (MAD), and low-glycemic-index treatment (LGIT) in children (≤18 years) with DRE. Two reviewers independently screened studies, extracted data, and assessed quality using the Cochrane Risk of Bias Tool 2.0. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed- or random-effects models. Results: Nine studies met the inclusion criteria. For patients achieving >50% seizure reduction, pooled analysis (random-effects model; I Conclusion: The KD significantly improved seizure outcomes, with robust efficacy in reducing seizure frequency and a higher likelihood of achieving seizure freedom, although absolute rates of seizure freedom were modest. These findings support the KD as a promising adjunctive therapy for children with drug-resistant epilepsy; however, further large-scale, long-term studies are needed to confirm its sustained efficacy and safety. Systematic review registration: CRD420251122427.
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