SynthesisFrontiers in nutrition2025
High-protein oral nutritional supplement use in patients with cancer reduces complications and length of hospital stay: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Impact of oral nutritional supplements on chemotherapy tolerance and overall survival in postoperative colorectal cancer patients undergoing chemotherapy.Asia Pacific journal of clinical nutrition · 2026Trial
- Article
- Article
- Nutritional rehabilitation strategies in abdominal surgery.Current opinion in clinical nutrition and metabolic care · 2026Review
- The association between radiographic osteosarcopenia and overall mortality among older patients undergoing colorectal cancer resection.Aging clinical and experimental research · 2026Article
- Clinical field survey and multidisciplinary expert in-depth interview study on food for special medical purpose products for patients.Clinical nutrition research · 2026Article
- Dose-response relationships between early postoperative nutrition and subsequent complications in gastrointestinal cancer: optimal intake ranges for energy and protein.Frontiers in nutrition · 2026Article
- Malnutrition and Sarcopenia in Patients with Neuroendocrine Tumors: A Comprehensive Review of Evidence.Biomolecules · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Oral nutritional supplements (ONS) have been reported to improve nutritional status, quality of life and clinical outcomes in many patient groups. This systematic review investigated the effects of high-protein ONS (HPONS), ≥20% energy from protein, on clinical outcomes in cancer patients. Methods: A systematic review (searches to January 2025) identified 32 publications reporting results from 29 randomised controlled trials (RCTs) ( Results: Meta-analysis showed a significant overall reduction (101 fewer per 1,000 patients) in complications (15RCTs, Conclusion: This systematic review and meta-analysis provide evidence that the use of HPONS (including those enriched with omega-3 fatty acids) alongside dietary intake is associated with a significant reduction in complications and LOS in cancer patients. The review found no significant effects on hospital readmissions or mortality. Given the heterogeneity of the patient population, further investigation is needed to comprehensively evaluate the effect of nutritional support on patient outcomes according to specific cancer and treatment types in various clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.