Evidence map›Paper›PMID 41001137›Full record

ReviewPostepy dermatologii i alergologii2025

The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7.

Anna Starzyńska, Aleksandra Sejda, Łukasz Adamski, Paulina Adamska, Rafał Pęksa, Monika Sakowicz-Burkiewicz, Piotr Wychowański, Barbara A Jereczek-Fossa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Postepy dermatologii i alergologii, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna StarzyńskaDepartment of Oral Surgery, Medical University of Gdansk, Poland.
Aleksandra SejdaDepartment of Pathomorphology and Forensic Medicine, University of Warmia and Mazury, Olsztyn, Poland.
Łukasz AdamskiDepartment of Oral Surgery, Medical University of Gdansk, Poland.
Paulina AdamskaDepartment of Oral Surgery, Medical University of Gdansk, Poland.
Rafał PęksaDepartment of Pathomorphology, Medical University of Gdansk, Poland.
Monika Sakowicz-BurkiewiczDepartment of Molecular Medicine, Medical University of Gdansk, Poland.
Piotr WychowańskiDivision of Oral Surgery and Implantology, Department of Head and Neck and Sensory Organs, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", Rome, Italy.
Barbara A Jereczek-FossaDivision of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The most common malignant neoplasm of the oral cavity is squamous cell carcinoma. It accounts for over 95% of malignant lesions in this area and is characterised by rapid spread and distant metastases. Aim: To collect and review the data on B7 family proteins as prognostic factors in oral squamous cell carcinoma and to describe their role in aggressive disease progression. Methods: A systematic review of the literature about B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7, was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 9 articles published before 22 May 2020 were included in the systematic review. Results: The biggest study group consisted of 201 patients and the smallest - 40 patients. B7-1, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7 protein expressions were prognostic factors. Overall survival was significantly associated with B7-H3, B7-H5, B7-H6 and B7-H7. Immunohistochemistry was the diagnostic method used in all the studies. Conclusions: The data presented indicate the complexity of cellular and molecular processes related to the formation, development and invasion of oral cancer. Mutations in genes encoding the B7 family and changes in the B7 protein pathway may affect the prognosis of survival in patients with oral squamous cell carcinoma.

Indexed as

B7 antigensoral cavitysquamous cell carcinoma

Identifiers

PMID41001137
PMCPMC12458067

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.