Evidence map›Paper›PMID 41001346›Full record

ArticleFrontiers in pharmacology2025

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury.

Niklas Larsson, Cindy B McReynolds, Sung Hee Hwang, Debin Wan, Jun Yang, Richard Lindberg, Stefan Lehtipalo, Jonas Claesson, Amanda Irgum Liljeström, Alicia Lind and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Niklas LarssonAnesthesiology and Intensive Care, Department of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Cindy B McReynoldsDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, United States.
Sung Hee HwangDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, United States.
Debin WanDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, United States.
Jun YangDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, United States.
Richard LindbergDepartment of Chemistry, Umeå University, Umeå, Sweden.
Stefan LehtipaloAnesthesiology and Intensive Care, Department of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Jonas ClaessonAnesthesiology and Intensive Care, Department of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Amanda Irgum LiljeströmAnesthesiology and Intensive Care, Department of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Alicia LindAnesthesiology and Intensive Care, Department of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Anders BrolinAnesthesiology and Intensive Care, Department of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Martin Isaksson MettävainioDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.
Bruce D HammockDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, United States.
Christophe MorisseauDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, United States.
Malin L NordingDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, United States.

Funding

TRANSPORT, TRANSFORMATION &REMEDIATION OF VOCS IN THE VADOSE ZONE &GROUND WATERP42ES004699 · UNIVERSITY OF CALIFORNIA DAVIS · 1987 to 2005
$14.0M
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseasesR35ES030443 · UNIVERSITY OF CALIFORNIA AT DAVIS · 2025 to 2025
$1.0M
NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443
6 · The paper itself

Abstract

Pharmacological inhibition of soluble epoxide hydrolase has been shown to attenuate lung injury development in rodents exposed to bacterial lipopolysaccharide. To investigate if these effects can be reproduced in larger animals, we tested soluble epoxide hydrolase (sEH) inhibition using an sEH inhibitor 1-adamantanyl-3-{5-[2-(ethylethoxy)ethoxy]pentyl}urea (AEPU) in a porcine model of lipopolysaccharide-induced acute lung injury. AEPU was selected from 23 sEH inhibitors based on IC50 values and metabolic stability profiles established by a fluorescent based activity assay and porcine liver microsomal test, respectively. Hydrolysis of fatty acid epoxides to their corresponding diols is catalyzed by sEH. Inhibition of sEH reduces this conversion, leading to an accumulation of epoxides relative to diols. Hence, AEPU-treated subjects (n = 9) showed metabolic signs of effective

Indexed as

acute respiratory distress syndromeAEPUlipid mediatorslung injurysoluble epoxide hydrolase

Identifiers

PMID41001346
PMCPMC12457078

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.