Evidence map›Paper›PMID 41001383›Full record

SynthesisFrontiers in medicine2025

The relationship between initial vitamin D levels and

Leony Octavia, Dwi Andhika Panjarwanto, Putri Nabila, Putri Lenggo Geany, R Mohamad Javier, Aldo Aulia Rahman, Vallexa Septina Yora, Lucky Sutanto, Arthur Peter Tandayu, Srigita Varsha and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leony OctaviaFaculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Dwi Andhika PanjarwantoFaculty of Medicine, Brawijaya University, Malang, Indonesia.
Putri NabilaFaculty of Medicine, Pelita Harapan University, Tangerang, Indonesia.
Putri Lenggo GeanyFaculty of Medicine, Diponegoro University, Semarang, Indonesia.
R Mohamad JavierDepartment of Cardiology and Vascular, RS University of Indonesia, Depok, Indonesia.
Aldo Aulia RahmanFaculty of Medicine, Sriwijaya University, Palembang, Indonesia.
Vallexa Septina YoraFaculty of Medicine, Muhammadiyah Malang University, Malang, Indonesia.
Lucky SutantoMilitary Hospital of the Indonesian Army Kartika Husada, Tanjungpura, Indonesia.
Arthur Peter TandayuFaculty of Medicine, Brawijaya University, Malang, Indonesia.
Srigita VarshaFaculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Sofyan SolichinFaculty of Medicine, Brawijaya University, Malang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting reproductive-age women and is often associated with infertility challenges. Recent studies suggest that vitamin D levels play a significant role in reproductive outcomes, particularly in PCOS patients undergoing Methods: A systematic review was conducted following PRISMA guidelines. Studies published between 2014 and 2024 were analyzed, focusing on the impact of pre-treatment vitamin D levels on IVF outcomes such as fertilization rates, implantation rates, clinical pregnancy, and live birth rates. Only studies on PCOS-related infertility were included, while non-PCOS infertility cases were excluded. Result: The review examined 59 studies, highlighting variations in outcomes based on study design and populations. Evidence generally supports the hypothesis that adequate vitamin D levels are associated with improved IVF success, though inconsistencies remain. Further research is recommended to standardize supplementation protocols and better understand vitamin D's biological mechanisms in reproductive health. Conclusion: The relationship between initial vitamin D levels and Systematic review registration: CRD42024622381, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024622381.

Indexed as

in vitro fertilizationpolycystic ovary syndromereproductive outcomessystematic reviewvitamin D

Identifiers

PMID41001383
PMCPMC12457413

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.