ArticlemedRxiv : the preprint server for health sciences2025
Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Recovery from aphasia after stroke is thought to depend on functional reorganization of language processing in surviving brain regions. Many studies have investigated this process, but progress has been impeded by methodological limitations relating to task performance confounds, contrast validity, and sample sizes. Furthermore, few studies have accounted for the complex relationships that exist between patterns of structural damage, distributed networks of functional activity, and behavioral outcomes. The present cross-sectional study aimed to overcome these critical methodological limitations and to disentangle the relationships between structure, function, and behavior. We recruited 70 individuals with post-stroke aphasia and 45 neurologically normal comparison participants. We used a valid and reliable language mapping fMRI paradigm that adapted dynamically to each participant's task performance, and carried out whole-brain permutation analyses along with hypothesis-driven analyses of individually defined functional regions of interest (ROIs). Multivariable models were constructed that incorporated lesion load estimates derived from machine learning and language activations across multiple brain regions. We found strong evidence that left posterior temporal cortex is the most critical region for language processing in post-stroke aphasia: functional activity in this region was reduced in aphasia, predictive of aphasia outcomes in a whole-brain analysis above and beyond the contribution of lesion load, and remained predictive even above and beyond other functional predictors, with a medium effect size (
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