Evidence map›Paper›PMID 41001557›Full record

ArticleResearch square2025

Mutation of platelet-derived growth factor receptor β causes and exacerbates the severity of brain arteriovenous malformation through enhancing angiogenesis.

Alka Yadav, Leandro Barbosa Do Prado, Mustafa Mohamed, Calvin Wang, Joshua Shi, Zahra Shabani, Rich Liang, Kelly Press, Courtney Tom, Ethan A Winkler and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alka YadavCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Leandro Barbosa Do PradoCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Mustafa MohamedCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Calvin WangCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Joshua ShiCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Zahra ShabaniCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Rich LiangCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Kelly PressCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Courtney TomCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
Ethan A WinklerDepartment of Neurosurgery, University of California, San Francisco, California, USA.
Hua SuCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.ORCID 0000-0003-1566-9877

Funding

Uncover the Pathogenesis of Brain Arteriovenous MalformationR01NS027713 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SU, HUA · 1990 to 2023
$8.6M
Reduction of Brain AVM Severity through Inhibition of Pathogenic AngiogenesisR01NS112819 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SU, HUA · 2020 to 2024
$2.9M
Cell type-specific influences on HHT pathogenesisR01HL122774 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SU, HUA · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL122774NINDS NIH HHS R01 NS027713NINDS NIH HHS R01 NS112819
6 · The paper itself

Abstract

Brain arteriovenous malformations (bAVMs) are tangles of abnormal vessels that shunt blood directly from arteries to Veins. The reduction of pericytes is linked to hemorrhage in bAVMs. The PDGFB/PDGFRβ signaling pathway is crucial for regulating pericyte recruitment during angiogenesis. Here, we show that mutation of

Indexed as

Alk1Brain arteriovenous malformationendoglinpericyteplatelet-derived growth factor receptor-β

Identifiers

PMID41001557
PMCPMC12458561

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.