Evidence map›Paper›PMID 41001621›Full record

ArticleJACS Au2025

Light-Sensitive Ion Channel Delivery System for Ion-Interference Tumor Therapy.

Yueyue Lu, Yuxin Wu, Canhong Zhu, Tianlong Zhang, Yanting Wu, Lulu Xi, Xianze Huang, Tengfei Yan, Junqiu Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yueyue LuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Yuxin WuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Canhong ZhuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Tianlong ZhangKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Yanting WuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Lulu XiKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Xianze HuangKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Tengfei YanKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Junqiu LiuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory ofOrganosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.ORCID https://orcid.org/0000-0003-1608-7908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial ion channels have shown great potential applications in tumor treatment by disrupting ion homeostasis across cancer cell membranes. Herein, we report a de novo-designed ion channel delivery system (ICDS) based on light-sensitive nanocapsules that can induce cell apoptosis via interfering with ion homeostasis of subcellular membranes of tumors. The nanocapsules were self-assembled by the host-guest complex of azobenzene-modified quinoline helix (an artificial proton channel) and α-cyclodextrin, which can easily enter tumor cells by an endocytic effect and release proton channels under ultraviolet (UV) light irradiation. The artificial proton channels further neutralize the acidic organelles (such as lysosomes), deplete the mitochondrial membrane potential, elevate reactive oxygen species (ROS) levels, and eventually induce the apoptosis of cancer cells. As far as we know, this is the first example of an ion-interference antitumor strategy by an ion channel delivery system that may offer novel therapeutic directions for artificial ion channels.

Indexed as

artificial proton channelcell apoptosision channel delivery systemnanocapsulequinoline helix

Identifiers

PMID41001621
PMCPMC12458000

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.