ArticleJACS Au2025
Correlated Segments of Intrinsically Disordered Proteins as Drivers of Homotypic Phase Separation.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Many studies have suggested that amino acid composition, not their positions along the sequence, is the determinant of phase separation of intrinsically disordered proteins (IDPs). In particular, aromatic amino acids and Arg have been identified as major drivers. Here I underscore the importance of the positions of amino acids along the sequence in phase separation. Specifically, clusters of interaction-prone amino acids, including Trp and Arg, along the sequence form correlated segments, and these correlated segments, rather than individual residues, drive the phase separation of many IDPs. Correlated segments manifest themselves as stretches of residues that span major peaks in the backbone
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