ArticleFrontiers in endocrinology2025
Neurodevelopmental trajectories in well-controlled gestational diabetes mellitus offspring: No differences were found at the 6- and 12-month assessments.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To examine the associations between well-controlled gestational diabetes mellitus (GDM) and early neurodevelopmental trajectories in offspring. Methods: This retrospective cohort study included 2810 mother-infant pairs from Guangdong Women and Children Hospital (2016-2022). GDM was diagnosed via a 75 g oral glucose tolerance test at 24-28 gestational weeks, and women with well-controlled GDM were those who maintained blood glucose levels defined as a third-trimester HbA1c < 6% without requiring medication. Neurodevelopment was assessed via the Children's Neuropsychological and Behavioral Scale-Revision 2016 at 6 and 12 months of age. Results: Among 2810 mother-infant pairs, 451 (16.05%) were diagnosed with GDM. Compared with non-GDM mothers, mothers with GDM had a greater median age (31.00 Conclusions: Well-controlled GDM was not associated with adverse neurodevelopmental outcomes in early infancy, suggesting that optimized perinatal management may mitigate risks.
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