ArticleAnnals of clinical and translational neurology2026
Altered Dynamic Functional Network Connectivity in Post-Stroke Aphasia.
Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Dynamic functional reorganization in post-stroke aphasia: a state-of-the-art fMRI review from disease evolution to intervention.Frontiers in neuroscience · 2026Review
- Synergistic neuroplasticity from synchronous Taiji Yunshou and tDCS in stroke: an fNIRS study of cortical activation and cross-subject hemodynamic brain network.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivePrevious studies examining post-stroke aphasia (PSA) patients via resting-state functional magnetic resonance imaging (rs-fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients.
methodsWe recruited 40 PSA patients and 41 age-, gender-, and education-matched normal controls (NCs). The participants underwent rs-fMRI and the Western Aphasia Battery (WAB) test. Independent component analysis (ICA) was used to identify resting-state networks (RSNs), and dFNC was constructed using a sliding window technique followed by k-means clustering to classify distinct dynamic network states. We compared the dFNC differences between the PSA and NC groups and examined their relationships with clinical outcomes.
resultsThe dynamic analysis identified 4 distinct dFNC states: state 1 (modular network state), state 2 (pan-network hyperconnectivity state), state 3 (intra-network coordinated state), and state 4 (sparse connectivity state). Notable group differences were observed: compared with NCs, the PSA group demonstrated significantly reduced connectivity within the language network (LN) and increased connectivity between the cerebellar network (CN) and the default mode network (DMN) in state 3; significantly reduced connectivity changes within the LN and between the LN and executive control network (ECN) / CN were noted in state 4. Additionally, fraction time and mean dwell time in the modular network state were positively correlated with the WAB score.
interpretationAlteration in dFNC could serve as a sensitive biomarker toward language impairment in PSA patients, with implications for diagnostic assessment and therapeutic intervention planning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.