Evidence mapPaperPMID 41002349Full record

ReviewBiosensors2025

Deep Learning-Driven Multimodal Integration of miRNA and Radiomic for Lung Cancer Diagnosis.

Yuanyuan Chen, Dikang Chen, Xiaohui Liu, Hui Jiang, Xuemei Wang

Abstract readReview
In one paragraph

Review in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanyuan ChenState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.ORCID 0009-0007-1806-6787
Dikang ChenState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Xiaohui LiuState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Hui JiangState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.ORCID 0000-0001-8044-758X
Xuemei WangState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

Funding

National Natural Science Foundation of China 82027806National Natural Science Foundation of China 82061148012National Natural Science Foundation of China 82372220National Natural Science Foundation of China 92461308
6 · The paper itself

Abstract

Lung cancer remains one of the most common and deadly malignancies worldwide. Current diagnosis and staging primarily rely on biopsy techniques, which fail to comprehensively characterize the molecular profiles and tumor microenvironment. Current studies demonstrate the promising performance (AUC = 82%) of miRNA-based predictive models, but exclusive reliance on miRNA signatures is limited by incomplete capture of tumor heterogeneity. Integrating imaging and genomic data can further enhance model accuracy, with functional nanomaterials serving as core advanced biosensing platforms to bridge miRNA sensing and radiomic fusion. Consequently, integrating imaging and genomic data can further enhance model accuracy. Recent research employing DenseNet architecture for the multimodal fusion of miRNA and radiomic features achieved an AUC of 0.98 with 85.7% sensitivity. This review summarizes advances in miRNA biomarkers, deep learning-driven radiogenomics, and critical roles of functional nanomaterials in biosensing-enabled multimodal integration, along with challenges and future directions for clinical translation.

Indexed as

Deep LearningLung NeoplasmsMicroRNAsBiomarkers, TumorBiosensing TechniquesHumansRadiomicsBiomarkers, TumorMicroRNAsdeep learninglung cancermiRNA biomarkersmiRNA-seqmultimodal analysisradiomic

Identifiers

PMID41002349
PMCPMC12467605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.