ArticleCells2025
TLR4 rs2149356 Polymorphism in Periodontitis and End-Stage Renal Disease: An Exploratory Analysis in Egyptian Patients.
Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Periodontitis as a potential amplifier of diabetes-related genitourinary complications: evidence gradients and mechanistic insights into the inflammation-microvascular injury axis.Frontiers in cellular and infection microbiology · 2026Review
- Association of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms With Susceptibility to Periodontitis: A Systematic Review and Meta-Analysis With Exploratory Analysis of Apical Periodontitis.International journal of dentistry · 2026Review
- Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explored the association of the TLR4 rs2149356 polymorphism with periodontal and renal parameters in Egyptian end-stage renal disease (ESRD) patients. Ninety-two patients with periodontitis were recruited, forty-six on hemodialysis, and forty-six systemically healthy controls. Clinical periodontal indices, renal biomarkers, and gGenotyping for TLR4 rs2149356 were assessed. Gingival inflammation was significantly higher in ESRD patients across all genotypes. Although the TT genotype showed a trend toward deeper probing depths and greater attachment loss in ESRD patients, these differences did not reach statistical significance after correction. Regression models indicated that TT carriers exhibited higher inflammatory and renal burden, suggesting a potential gene-environment interaction. TLR4 rs2149356 polymorphism may modulate inflammatory response in ESRD and periodontitis patients, although findings remain exploratory. These results highlight the potential role of host-microbe-gene interactions in systemic inflammation, warranting longitudinal and functional studies in larger, multi-ethnic cohorts.
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Registered trials
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