Evidence map›Paper›PMID 41002396›Full record

ArticleCells2025

Multi-Strain Probiotic Lysate Attenuates TGF-β1-Induced Intestinal Fibrosis and EMT Modulating Smad, Akt, and WNT/β-Catenin Pathways.

Alessia Ciafarone, Serena Artone, Valeria Ciummo, Francesca Rosaria Augello, Serena Altamura, Francesca Lombardi, Giovanni Latella, Paola Palumbo, Benedetta Cinque

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Alessia CiafaroneDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0009-0002-7862-3323
Serena ArtoneDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Valeria CiummoDepartment of Innovative Technologies in Medicine and Dentistry, University "G. d'Annunzio", 66100 Chieti, Italy.ORCID 0009-0009-8070-2531
Francesca Rosaria AugelloDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Serena AltamuraDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-7146-3852
Francesca LombardiDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-0551-5076
Giovanni LatellaDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-6341-5711
Paola PalumboDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-7027-2691
Benedetta CinqueDepartment of Life, Health & Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0003-4510-9416

Funding

University of L'Aquila 06VITALITY_PALUMBO
6 · The paper itself

Abstract

Intestinal fibrosis is a common complication of inflammatory bowel diseases (IBD), and, to date, effective and safe antifibrotic drugs are still lacking. Emerging evidence suggests that probiotics may provide novel strategies to counteract fibrotic processes. In this study, we evaluated the anti-fibrotic potential of a multi-strain probiotic formulation,

Indexed as

Epithelial-Mesenchymal TransitionIntestinesProbioticsProto-Oncogene Proteins c-aktSmad ProteinsTransforming Growth Factor beta1Wnt Signaling Pathwaybeta CateninCaco-2 CellsCell ProliferationFibroblastsFibrosisHumansbeta CateninProto-Oncogene Proteins c-aktSmad ProteinsTransforming Growth Factor beta1epithelial-to-mesenchymal transition (EMT)fibroblast-to-myofibroblast transitionfibrotic signaling pathwayinflammatory bowel disease (IBD)intestinal epithelial cellsintestinal fibroblastsintestinal fibrosismulti-strain probioticsTGF-β1 signaling

Identifiers

PMID41002396
PMCPMC12468314

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.