Evidence map›Paper›PMID 41002435›Full record

ArticleCells2025

Frog Skin Antimicrobial Peptide 3-13 and Its Analogs Alleviate Atherosclerosis Cholesterol Accumulation in Foam Cells via PPARγ Signaling Pathway.

Xue-Feng Yang, Zi-Meng Hao, Xin-Yu Cui, Wan-Qi Liu, Meng-Miao Li, De-Jing Shang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xue-Feng YangSchool of Life Science, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China.ORCID 0000-0002-8455-3926
Zi-Meng HaoSchool of Life Science, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China.
Xin-Yu CuiSchool of Life Science, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China.
Wan-Qi LiuSchool of Life Science, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China.
Meng-Miao LiSchool of Life Science, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China.
De-Jing ShangSchool of Life Science, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China.

Funding

Key Research Project of Liaoning Provincial Department of Education JYTZD2023102National Natural Science Foundation of China 32070440
6 · The paper itself

Abstract

Atherosclerosis (AS), a major contributor to cardiovascular disease, hypertension, and stroke, is associated with significant morbidity and mortality. Antimicrobial peptides (AMPs) 3-13, W3R6, and chensinin-1b were engineered based on the sequence of chensinin-1, originally isolated from the skin secretion of

Indexed as

Antimicrobial PeptidesAtherosclerosisCholesterolFoam CellsPPAR gammaSignal TransductionSkinAnimalsAnuraATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CD36 AntigensHumansMaleMiceMice, Inbred C57BLAntimicrobial PeptidesATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CD36 AntigensCholesterolPPAR gammaatherosclerosisfrog skin antimicrobial peptidelipid metabolismPPARγ

Identifiers

PMID41002435
PMCPMC12468074

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.