ArticleGels (Basel, Switzerland)2025
Tuning Pluronic Hydrogel Networks: Effects of Vancomycin Loading on Gelation, Rheological Properties, and Micellar Structures.
Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Injectable Thermosensitive Composite Hydrogels for Sustained Nanoparticle Delivery and Enhanced Wound Healing.Gels (Basel, Switzerland) · 2026Article
- Construction and Activity of Cisplatin-Loaded Chitosan-Zinc Amino-Porphyrin Photosensitizer Hydrogel.Gels (Basel, Switzerland) · 2025Article
- Implementation of a Potential Industrial Green, Economical, and Safe Strategy to Enhance Commercial Viability of Liquid Self-Nanoemulsifying Drug Delivery System.Pharmaceutics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Thermoresponsive Pluronic hydrogels offer a promising platform for localised antibiotic delivery. However, how drug loading affects the structural integrity and gelation of these systems remains underexplored. This study evaluates the impact of vancomycin on the physicochemical and self-assembly behaviour of Pluronic F127, F108, and F68 hydrogels. Rheological analysis revealed that vancomycin altered the critical micellisation and gelation temperatures (CMT and CGT, respectively), accelerating gelation in weak gel systems but disrupting network formation in stronger gels. Small-angle X-ray scattering (SAXS) showed that vancomycin suppressed micellar ordering, particularly along FCC (111) planes in F127, without inducing a phase transition. Scanning electron microscopy (SEM) imaging confirmed reduced pore integrity in vancomycin-loaded F127 and F108 gels, while 35% F68 gels failed to form stable structures at the tested concentrations despite enhanced drug solubility. F127 (18%) and F108 (22-23%) maintained gelation at 37 °C with reasonable mechanical strength and partial cubic ordering, making them suitable candidates for drug-eluting gels. These findings inform the design of thermoresponsive hydrogels for localised, implant-associated antibiotic delivery.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.