Evidence map›Paper›PMID 41002480›Full record

ReviewGels (Basel, Switzerland)2025

Biological Models for Evaluating Hydrogel-Based Formulations in Wound Healing.

Ioana Baldea, Ioana Georgeta Grosu, Sahar Ghafury, Cristian Golat, Doriane Doubali, Ana-Maria Vestemean, Aris Nicolas Cedorge, Ilinca Florian, Michael Yiannoulatos, Muhammad Mudassir Wajahat and 3 more

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. A novel integratedRegenerative biomaterials · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ioana BaldeaDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.ORCID 0000-0003-4046-7310
Ioana Georgeta GrosuNational Institute for Research and Development of Isotopic and Molecular Technologies, Donat 67-103, 400293 Cluj-Napoca, Romania.
Sahar GhafuryDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Cristian GolatDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Doriane DoubaliDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Ana-Maria VestemeanDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Aris Nicolas CedorgeDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.ORCID 0009-0005-7480-2756
Ilinca FlorianDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Michael YiannoulatosDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Muhammad Mudassir WajahatDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Lorenzo Raoul SilliDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Thesseus StavrouDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.
Daniela Rodica MitreaDepartment of Physiology, University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, Romania.

Funding

Ministry of Education and Research, Romania project no. 27N/03.01.2023, component project code PN 23 24 01 05
6 · The paper itself

Abstract

Skin, the largest organ of the human body, serves as a critical physico-chemical barrier against environmental insults and plays essential roles in hydration, thermoregulation, immune defense, and metabolic functions. Wound healing is a complex, multistage biological process involving hemostasis, inflammation, proliferation, and remodeling. Hydrogels have emerged as a promising class of wound dressings due to their high moisture retention, biocompatibility, and ability to mimic the extracellular matrix, thereby supporting accelerated healing and controlled drug delivery. This review provides a comprehensive overview of current hydrogel types-classified by origin, crosslinking mechanisms, and responsiveness to stimuli-and evaluates their use in experimental research on in vitro, ex vivo, and in vivo wound healing models. Furthermore, clinical applications of hydrogels in wound therapy are discussed. Advances in semisynthetic and stimuli-responsive hydrogels, along with improved testing models, offer enhanced therapeutic potential and underscore the need for continued innovation to optimize wound care outcomes and alleviate healthcare burdens.

Indexed as

burn wound modelcrosslinked hydrogelsfull-thickness skin modelhydrogel-based dressingsreconstructed human epitheliumscratch assaysurgical wound modelwound healing models

Identifiers

PMID41002480
PMCPMC12469554

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.