Evidence map›Paper›PMID 41002516›Full record

ArticleGels (Basel, Switzerland)2025

Amphiphilic Thermoresponsive Triblock PLA-PEG-PLA and Diblock mPEG-PLA Copolymers for Controlled Deferoxamine Delivery.

Nikolaos D Bikiaris, Ermioni Malini, Evi Christodoulou, Panagiotis A Klonos, Apostolos Kyritsis, Apostolos Galaris, Kostas Pantopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nikolaos D BikiarisLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Ermioni MaliniLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Evi ChristodoulouLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-2730-0778
Panagiotis A KlonosLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-7222-612X
Apostolos KyritsisDielectrics Research Group, Department of Physics, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece.ORCID 0000-0001-5893-7849
Apostolos GalarisLady Davis Institute for Medical Research Montreal, and Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.ORCID 0000-0002-7367-7675
Kostas PantopoulosLady Davis Institute for Medical Research Montreal, and Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.ORCID 0000-0002-2305-0057

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study focuses on the synthesis and characterization of thermoresponsive hydrogels of poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG), PLA-PEG copolymers, aiming at the targeted and controlled release of deferoxamine (DFO), a clinically applied iron-chelating drug. Triblock (PLA-PEG-PLA) and diblock (mPEG-PLA) copolymers were synthesized using ring-opening polymerization (ROP) with five different PEGs with molecular weights of 1000, 1500, 2000, 4000, and 6000 g/mol and two types of lactide (L-lactide and D-lactide). Emulsions of the polymers in phosphate-buffered saline (PBS) were prepared at concentrations ranging from 10% to 50%

Indexed as

controlled drug releasedeferoxamineemulsionshydrogelmicellespoly(ethylene glycol)poly(lactic acid)thalassemiathermoresponsive polymers

Identifiers

PMID41002516
PMCPMC12469683

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.