Evidence map›Paper›PMID 41002528›Full record

ArticleGels (Basel, Switzerland)2025

Viscoelastic Properties and Enzymatic Degradation of Crosslinked Hyaluronic Acid for Deep Dermal Filler Use.

Alejandro Melero, Jon Andrade Del Olmo, Nagore Martínez de Cestafe, Claudia Goenaga Ibeas, Miguel Ucelay López de Heredia, Jon Kepa Izaguirre, José María Alonso, Raúl Pérez González

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. 3D Bioprinting of Blood Vessel Model for Improving Wound Healing.International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alejandro Meleroi+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.
Jon Andrade Del Olmoi+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.ORCID 0000-0002-6595-8776
Nagore Martínez de Cestafei+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.
Claudia Goenaga Ibeasi+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.
Miguel Ucelay López de Herediai+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.
Jon Kepa Izaguirrei+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.ORCID 0000-0001-7097-4845
José María Alonsoi+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.ORCID 0000-0002-9527-8333
Raúl Pérez Gonzálezi+Med S. Coop., Alava Technology Park, C/Hermanos Elhuyar 6, 01510 Vitoria-Gasteiz, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crosslinked hyaluronic acid dermal fillers are widely used for non-permanent aesthetic enhancement, offering safe and effective solutions for facial volume restoration. Specific formulations are designed for targeted facial regions, with highly crosslinked hydrogels often recommended for volumizing areas such as the jawline, chin, and cheeks due to their structural properties. While elasticity and viscosity are commonly evaluated, broader comparative analyses remain limited. In this study, we assess five commercially available HA-based fillers with similar HA concentrations, all optimised for volume enhancement. Alongside widely used reference products, we evaluate BtHCROSS 2%

Indexed as

aesthetic medicinecrosslinked hyaluronic aciddermal fillersfacial volume restoration

Identifiers

PMID41002528
PMCPMC12469832

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.