Evidence map›Paper›PMID 41002532›Full record

ReviewGels (Basel, Switzerland)2025

Research Progress of Sodium Alginate-Based Hydrogels in Biomedical Engineering.

Juan Cao, Bo Wu, Ping Yuan, Yeqi Liu, Cheng Hu

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Juan CaoSchool of Fashion and Design Art, Sichuan Normal University, Chengdu 610066, China.
Bo WuSchool of Mechanical Engineering, Sichuan University, Chengdu 610065, China.
Ping YuanSchool of Mechanical Engineering, Chengdu University, Chengdu 610106, China.
Yeqi LiuSchool of Mechanical Engineering, Sichuan University, Chengdu 610065, China.
Cheng HuNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.ORCID 0000-0003-4316-231X

Funding

Fundamental Research Funds for the Central Universities 2023SCUH0011Fundamental Research Funds for the Central Universities YJ2021115National Key Research and Development Programs, China 2023YFC2412802National Natural Science Foundation of China 32301115Natural Science Foundation of Sichuan Province 2025ZNSFSC0245
6 · The paper itself

Abstract

Sodium alginate, a widely available and high-performance natural polymer, exhibits significant potential for applications in the biomedical field due to its excellent biocompatibility and versatile functionalization capabilities. This review systematically elucidates the fundamental properties and preparation methods of sodium alginate-based hydrogels, analyzing recent advancements in optimizing their mechanical properties, functionalization, and biological characteristics through strategies such as composite material construction, nano-reinforcement, and dynamic crosslinking. Furthermore, it summarizes the multifunctional applications of sodium alginate-based hydrogels in drug delivery, tissue engineering, and biosensing while addressing challenges in practical applications, including insufficient mechanical strength, regulating degradation rates, and maintaining stability in complex biological environments. To overcome these challenges, future research directions are proposed, including performance optimization, intelligent design, novel preparation techniques, and interdisciplinary collaboration, to facilitate the comprehensive transition of sodium alginate hydrogels from laboratory research to clinical applications. This review aims to provide a theoretical foundation and technical support for the fundamental research and biomedical applications of sodium alginate hydrogels while highlighting their promising prospects in addressing complex medical challenges.

Indexed as

biosensingdrug deliveryhydrogelssodium alginatetissue engineering

Identifiers

PMID41002532
PMCPMC12469324

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.