Evidence map›Paper›PMID 41002603›Full record

ArticleJournal of cardiovascular development and disease2025

Comparison of Immunomodulatory Therapies for Cardiovascular Clinical and Inflammatory Markers Outcomes in Mild to Moderately Ill Hospitalized Multisystem Inflammatory Syndrome in Children Patients.

Rashmitha Dachepally, Reem Sarkis, Alvaro DonaireGarcia, Meghana Kovvuri, Karunya Jayasimha, Adrija Chaturvedi, Amr Ali, Sirada Panupattanapong, Samir Latifi, Hemant Agarwal

Abstract read
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In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rashmitha DachepallyDepartment of Pediatric Critical Care Medicine, Children's Nebraska, Omaha, NE 68114, USA.
Reem SarkisPediatric Emergency Medicine, Akron Children's Hospital, Akron, OH 44302, USA.
Alvaro DonaireGarciaDepartment of Pediatric Critical Care, Driscoll Children's Hospital Rio Grande Valley, Edinburg, TX 78539, USA.ORCID 0000-0001-8700-970X
Meghana KovvuriDepartment of Pediatric Critical Care Medicine, Driscoll Children's Hospital, Corpus Christi, TX 78411, USA.
Karunya JayasimhaDepartment of Pediatric Cardiology, WVU Children's, Morgantown, WV 26506, USA.
Adrija ChaturvediDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Cleveland, OH 44106, USA.
Amr AliDepartment of Pediatric Cardiac Critical Care, WVU Children's, Morgantown, WV 26506, USA.ORCID 0000-0001-5222-2260
Sirada PanupattanapongDepartment of Pediatric Rheumatology, Cleveland Clinic Children's, Cleveland, OH 44106, USA.
Samir LatifiDepartment of Pediatric Critical Care, Cleveland Clinic Children's, Cleveland, OH 44106, USA.
Hemant AgarwalPediatric Emergency Medicine, Akron Children's Hospital, Akron, OH 44302, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optimal treatment for non-critically ill multisystem inflammatory syndrome in children (MIS-C) remains unclear. We evaluated short-term outcomes in mild to moderately ill hospitalized MIS-C patients fulfilling CDC 2020 and CDC/CTSE 2023 criteria and treated between April 2020 and March 2022 with either intravenous immunoglobulin (IVIG) monotherapy (Group A, n = 17) or IVIG plus corticosteroids (GC) (Group B, n = 22). Cardiovascular clinical parameters, inflammatory markers, and cardiac imaging were compared on days 1, 3, and 5 relative to day 0. The two groups had no significant differences in demographics or illness severity. Group B showed improvement in heart rate (17.8; 95% CI [9.74, 25.8]), mean blood pressure (5.63 [1.61, 9.64]), and body temperature (1.45 [0.94, 1.95]) by day 1, followed by improvement in albumin (0.43 [0.2, 0.84]), CRP (7.56 [3.0, 12.11]), D-dimer (2344 [488.7, 4200.2]), ferritin (1448 [-609.4, 3505.5]), fibrinogen (110 [44.4, 176]), lymphocyte count (1006 [63.5, 1948]), and NT-proBNP (2901 [-349.3, 6153]) by day 3 and left ventricular ejection fraction by day 4-5 (3.84 [0.55, 8.23]). All results were statistically significant (

Indexed as

cardiac involvementchildrenglucocorticoidsinflammatory biomarkersintravenous immunoglobulinMIS-Ctreatmentventricular function

Identifiers

PMID41002603
PMCPMC12471045

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.