ArticleJournal of cardiovascular development and disease2025
Association of Pan-Immune-Inflammation Value with All-Cause and Cardiovascular Mortality in Survivors of Myocardial Infarction: NHANES 2001-2018 Analysis.
Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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5 authors.
Funding
Abstract
backgroundInflammatory responses critically impact long-term outcomes in myocardial infarction (MI) survivors, yet few biomarkers comprehensively evaluate systemic immune-inflammatory status. This study assessed the prognostic utility of a novel marker-the pan-immune-inflammation value (PIV)-for predicting all-cause and cardiovascular mortality post-MI.
methodsUsing the National Health and Nutrition Examination Survey data (2001-2018), 1559 MI survivors were included. PIV was calculated as (neutrophils × platelets × monocytes)/lymphocytes. Weighted Cox models assessed the association between log-transformed PIV (LnPIV) and mortality. Restricted cubic spline (RCS) models explored non-linear dose-response relationships, and predictive performance was evaluated via time-dependent ROC analysis.
resultsOver a median 75-month follow-up, 675 deaths occurred. LnPIV showed significant non-linear associations with all-cause (
conclusionPIV demonstrates threshold-dependent mortality risk stratification in MI patients, particularly effective in high-inflammatory subgroups, offering a potential tool for personalized risk stratification.
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