Evidence mapPaperPMID 41002725Full record

ReviewDiseases (Basel, Switzerland)2025

Rafaela Cirillo de Melo, Paula Rothbarth Silva, Nathalia Marçallo Peixoto Souza, Mateus Santana Lopes, Wellington Martins de Carvalho Ragassi, Luana Mota Ferreira, Fabiane Gomes de Moraes Rego, Marcel Henrique Marcondes Sari

Abstract readReview
In one paragraph

Review in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rafaela Cirillo de MeloUndergraduation in Pharmacy, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.
Paula Rothbarth SilvaGraduation Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.
Nathalia Marçallo Peixoto SouzaGraduation Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.
Mateus Santana LopesGraduation Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.
Wellington Martins de Carvalho RagassiGraduation Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.
Luana Mota FerreiraGraduation Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.ORCID 0000-0001-9951-587X
Fabiane Gomes de Moraes RegoGraduation Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.ORCID 0000-0003-1726-8524
Marcel Henrique Marcondes SariGraduation Program in Pharmaceutical Sciences, Federal University of Paraná (UFPR), Curitiba 80210-170, PR, Brazil.ORCID 0000-0002-9913-9306

Funding

National Council for Scientific and Technological Development #407034/2023-4
6 · The paper itself

Abstract

BACKGROUND/

objectivesDiabetic neuropathy (DN) is one of the most common and disabling complications of diabetes mellitus (DM), affecting motor, sensory, and autonomic nerves. Genetic factors, particularly polymorphisms in the

methodsA comprehensive search of PubMed, Scopus, and Web of Science was performed in February 2025, following JBI and PRISMA-ScR guidelines. Observational studies involving individuals with DN and the genotyping of ACE polymorphisms were included. Scientometric mapping was conducted using the Bibliometrix package in RStudio to identify publication trends and key thematic terms.

resultsFrom 100 screened articles, 11 met the inclusion criteria. Most studies (72.7%) addressed diabetic peripheral neuropathy, while 27.3% investigated cardiac autonomic neuropathy. All studies analyzed the I/D polymorphism in intron 16 of the

conclusions

Indexed as

angiotensin-converting enzyme genebiomarkersdiabetic complicationshyperglycemiasingle-nucleotide polymorphism

Identifiers

PMID41002725
PMCPMC12468817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.