Evidence mapPaperPMID 41002730Full record

ReviewDiseases (Basel, Switzerland)2025

Decoding Microbiome's Role in Prostate Cancer Progression and Treatment Response.

Minas Sakellakis, Panagiota Resta, Evangelia Papagianni, Kassandra A Procter, Irene Belouka, Katerina Gioti, Fragkiski Anthouli-Anagnostopoulou, Dimitrios Chaniotis, Apostolos Beloukas

Abstract readReview
In one paragraph

Review in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minas SakellakisDepartment of Medicine, Jacobi North Central Bronx Hospital, The Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Panagiota RestaDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.
Evangelia PapagianniDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.
Kassandra A ProcterDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.ORCID 0009-0004-5413-3287
Irene BeloukaDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.
Katerina GiotiDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.ORCID 0000-0002-2698-9772
Fragkiski Anthouli-AnagnostopoulouDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.ORCID 0000-0001-9882-3221
Dimitrios ChaniotisDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.ORCID 0000-0003-2313-1305
Apostolos BeloukasDepartment of Biomedical Sciences, School of Health Sciences, University of West Attica, Egaleo, 12243 Athens, Greece.ORCID 0000-0001-5639-0528

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is the most common genitourinary malignancy in men, with a multifactorial etiology influenced by genetic, environmental, and microbial determinants. Although the prostate was traditionally considered sterile, advances in microbiome research have challenged this view, revealing potential links between microbial communities and PCa development, progression, and treatment response. This review synthesizes evidence on the gut, urinary, seminal fluid, and prostatic microbiomes, highlighting their potential contributions to PCa pathogenesis and therapeutic outcomes. Key studies utilizing next-generation sequencing (NGS), whole-genome sequencing (WGS), PCR, and metagenomic analyses have identified specific bacterial and fungal taxa associated with Pca; however, findings remain inconsistent across methodologies and cohorts. Microorganisms such as

Indexed as

gut microbiomemicrobial biomarkermicrobiotanext-generation sequencingprostate cancer

Identifiers

PMID41002730
PMCPMC12468272

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.