ReviewDiseases (Basel, Switzerland)2025
Exploring the Interplay of Antioxidants, Inflammation, and Oxidative Stress: Mechanisms, Therapeutic Potential, and Clinical Implications.
Review in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Review
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- Review
- Theoretical visualization of covalent and non-covalent interactions: molecular diversity and substituent effects governing the reactivity of Bulbophyllum bibenzyl derivatives.Molecular diversity · 2026Article
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- Exosome-loaded nanoradiosensitizers in radiotherapy for preventing post-irradiation tumor recurrence: mechanisms, preclinical evidence, and translational challenges.Discover nano · 2026Review
- Ocular Surface Inflammation as a Driver of Cornea Limbal Stem Cell Deficiency: Mechanisms and Implications.International journal of molecular sciences · 2026Review
- From Sea to Cell:Marine drugs · 2026Article
- Phenolic-Enriched Fractions ofCurrent issues in molecular biology · 2026Article
- Article
- Diet-Dependent Chemical Profiling and Bioactivity ofMolecules (Basel, Switzerland) · 2026Article
- Comparative Analysis of Two Dietary Saturated Fat Types on Metabolite Profiles Crossing the Blood-Brain Barrier of Poultry Chicks.Metabolites · 2026Article
- Superior Intracellular Antioxidant Activity of an Astaxanthin-Containing Corynebacterial Extract.International journal of molecular sciences · 2026Article
- Cytoprotective Effects of Agomelatine on Hepatic Ischemia-Reperfusion Injury in a Rat Model.International journal of molecular sciences · 2026Article
- Phytochemical Characterization and Antioxidant, Antimicrobial, and Poultry Meat Preservation Potential ofFoods (Basel, Switzerland) · 2026Article
- Taxifolin Attenuates Remote Lung Injury Induced by Hepatic Ischemia-Reperfusion in Rats.Molecules (Basel, Switzerland) · 2026Article
- Biological effects of 5G-modulated 700 MHz RF-EMF exposure on neuronal and glial cell models under isothermal conditions.Scientific reports · 2026Article
- Next-Generation Hydrogels Integrating Natural Antioxidants and Microbiome Modulators for Improved Cancer Management.Gels (Basel, Switzerland) · 2026Review
- Immunometabolic-uterine-ovarian interactions and flushing therapy in dairy cows: a narrative review.Veterinary world · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, is a major factor in chronic diseases such as cardiovascular disorders, neurodegeneration, diabetes, and cancer. Despite extensive research, current reviews often discuss antioxidants or inflammatory pathways separately, which limits their translational impact. The primary objective of this review is to present an integrated analysis of oxidative stress and inflammation, connecting molecular mechanisms with clinical evidence. We focus on the dual roles of natural and synthetic antioxidants in managing redox balance, regulating inflammatory signaling, and targeting new molecular pathways. Unlike previous work, this review emphasizes recent clinical findings, ongoing therapeutic challenges, and innovative strategies, including combination approaches and synthetic derivatives designed to improve effectiveness. By combining biochemical, preclinical, and clinical perspectives, we highlight both established knowledge and critical gaps. Ultimately, this review highlights the clinical significance of redox biology, clarifies the potential of antioxidant-based treatments, and outlines future research directions essential for translating these insights into effective therapies for chronic disease management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.