Evidence map›Paper›PMID 41002944›Full record

ArticleBiochemistry2025

Single Particle Dynamics of Protein Aggregation and Disaggregation in the Presence of the sHsp Proteins IbpAB.

Andrew Roth, YuChen Yang, Jason Puchalla, Hays S Rye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Andrew RothDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77845, United States.
YuChen YangDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77845, United States.ORCID 0009-0003-3338-8945
Jason PuchallaDepartment of Physics, Princeton University, Princeton, New Jersey 08544, United States.
Hays S RyeDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77845, United States.ORCID 0000-0002-9420-3137

Funding

Mechanism of protein aggregate recognition and disassembly by molecular chaperonesR01GM134063 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI RYE, HAYS S · 2019 to 2022
$1.4M
Mechanism of membrane fission at the recycling endosomeR01GM114405 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI RYE, HAYS S · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM114405NIGMS NIH HHS R01 GM134063
6 · The paper itself

Abstract

The small heat shock proteins (sHsps) are a key class of molecular chaperones that can inhibit protein aggregation and enhance protein recovery from aggregates. However, the mechanisms sHsps employ to carry out these roles are not well understood, in part because the highly heterogeneous and dynamic particles they form with aggregating proteins are difficult to study with traditional biophysical tools. Here we have applied a novel single particle fluorescence technique known as Burst Analysis Spectroscopy (BAS) to the study of the

Indexed as

Escherichia coliEscherichia coli ProteinsHeat-Shock ProteinsHeat-Shock Proteins, SmallProtein AggregatesParticle SizeSpectrometry, FluorescenceEscherichia coli ProteinsHeat-Shock ProteinsHeat-Shock Proteins, SmallIbpB protein, E coliProtein Aggregates

Identifiers

PMID41002944
PMCPMC12509322

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.